Browsing Human- und Zahnmedizin by Referee "Doenecke, Detlef Prof. Dr."
Now showing items 1-11 of 11
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Einfluss geschlechtsspezifischer Unterschiede des Speichels auf die Entwicklung dentaler Erosionen: eine In-situ-Studie
(2021-11-04)The aim of this study was to analyse if the erosion-protective potential of the salivary pellicle is different between female and male subjects. Bovine enamel and dentin specimens (each n = 3) were exposed to the oral ... -
Die CHD9-Genmutation der Maus und ihre Folgen für den Knochen
(2014-04-24)Abstract Klemm, Christin: The CHD9-Genmutation in mice and its effect on the bone This thesis is to show the connection between the CHD9-gene deletion in mice and its influence on different cell lines with special focus ... -
The Role of NS3 Helicase Domain in Hepatitis C Virus Particle Assembly
(2013-11-22)Hepatitis C virus non-structural protein 3 (NS3) is a multifunctional protein that obtains serine protease, RNA helicase and NTPase activities. The enzyme is essential for viral RNA replication. Its protease domain cleaves ... -
Interaktion der Organische-Anionen-Transporter 1 und 3 mit Dicarboxylaten
(2013-02-22)Organic anions are taken up from the blood into proximal tubule cells by organic anion transporters 1 and 3 (OAT1 and OAT3) in exchange for dicarboxylates. In this thesis the affinities of dicarboxylates for human OAT1 ... -
Klonierung und Expression einer extrazellulären Lipase von A. fumigatus
(2012-05-15)In Germany every year a great number of people contract invasive mould mycosis initiated by the fungus Aspergillus fumigatus. Almost solely severe immunocompromised patients are being affected. The infection with A. fumigatus ... -
Die inhibitorische Wirkung des Acylglucuronidmetaboliten der Mycophenolsäure auf die Inosinmonophosphatdehydrogenase Typ II
(2011-12-05)Mycophenolic acid (MPA), a widely used immunosuppressive agent, exerts its pharmakological action through uncompetitive inhibition of inosine monophosphate dehydrogenase type II (IMPDH-II), ... -
Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
(2010-06-09)AIMS:The tumor-initiating events in GISTs are activating mutations in the receptor tyrosin kinases KIT und PDGFRA. In contrast, little is known about tumor initiation in true leiomyogenal ... -
Regulation by Glycogen Synthase Kinase-3 Beta of CBP transcriptional coactivator involved in insulin-dependent glucagon gene transcription
(2007-02-12)The peptide hormone glucagon is a functional antagonist of insulin and it stimulates glucose output from the liver. Insulin inhibits glucagon secretion and glucagon gene transcription. ... -
Regulation of gene expression of hepcidin and of other proteins of the iron metabolism in the liver and in the extrahepatic tissues: in vivo and in vitro studies in different rat models.
(2006-12-04)Iron is an essential element required for many redox processes in all eukaryotes and most of the prokaryotes. Serum iron level decreases during microbial infection, inflammation or ... -
Molecular mechanisms of insulin resistance in glucagon-producing alpha cells
(2006-11-22)Type II diabetes mellitus is a chronic disease, affecting more than 150 million people worldwide. Type II diabetes mellitus is characterized by insulin resistance of peripheral tissues ... -
Transcriptional regulation of the Human Zfm1/Sf1 Gene
(2006-10-12)The first aim of the present study was to elucidate whether IL-1β/TNFα and/or PDGF down-regulate Zfm1 gene expression and induce proliferation also in human SMC. The results revealed that ...