Dokumente Human- und Zahnmedizin nach Gutachter "Dressel, Ralf Prof. Dr."
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Pharmakologische rho-Kinasen-Inhibition im H4-Zelllinien-Modell des Morbus Parkinson
(2024-04-26)Parkinson's disease (PD) is the most common neurodegenerative movement disorder, unfortunately there are no curative therapeutic approaches to date. Rho-associated protein kinase (ROCK) has been described as a novel ... -
Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Die biomechanische Analyse des Kiefergelenks mit Hilfe eines neuen Echtzeit-MRT-Verfahrens
(2024-04-03)Aim: The traditional hinge axis theory of temporomandibular joint (TMJ) dynamics is increasingly being replaced by the theory of instantaneous centers of rotation (ICR). Typically, ICR determinations are based on theoretical ... -
Auswirkungen einer Variation im TREM-1-Gen auf die Mortalität bei septischen Patienten
(2024-02-12)Sepsis is a life-threatening organ dysfunction caused by a disturbed immune response of the organism to an infectious agent. Sepsis is one of the most common causes of death in intensive care units. Due to its epidemiology ... -
MET-Alterationen als therapeutisches Target bei metastasierten kolorektalen Karzinomen
(2024-02-09)Introduction: An enhanced understanding of the molecular pathways driving oncogenesis has yielded an increasing number of potential therapeutic targets. MET amplification has been shown to be involved in angiogenesis, ... -
Kalziumhandling und Kalziumpufferung bei familiärer dilatativer Kardiomyopathie am Modell der induzierten pluripotenten Stammzellen
(2024-01-29)Dilated cardiomyopathy (DCM) is a heterogeneous disease characterised by left ventricular dilatation and a reduced ejection fraction. In addition to progressive left heart failure, the poor clinical prognosis is primarily ... -
PFKFB3-Inhibition während einer Radiochemotherapie des Rektumkarzinoms – Überprüfung in einem patient-derived xenograft In-vivo-Modell
(2024-01-29)Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and the second leading cause of cancer death. Approximately 30% of colorectal carcinomas are localized in the rectum. Neoadjuvant radiotherapy ... -
Ablationsbehandlung epikardialer akzessorischer Leitungsbahnen über das Koronarvenensystem bei Kindern und Jugendlichen
(2024-01-24)This retrospective data analysis was used to collect data from 24 patients ≤ 18 years who underwent ablation treatment of accessory pathways within the coronary venous system in Göttingen between October 2002 and December ... -
Untersuchungen zum Serin- und Glycin-Metabolismus und der Phosphoserin-Aminotransferase 1 in der Modellzelllinie P493-6
(2023-12-18)A fundamental trait of cancer cells is the reprogramming of cell metabolism. The complex genesis of aggressive non-Hodgkin lymphoma, such as diffuse large B-cell lymphoma (DLBCL), is accompanied by conversion of cellular ... -
Das Alter als Verteilungskriterium in der medizinischen humanitären Hilfe
(2023-11-13)Setting priorities in medical humanitarian aid is one of the most pressing issues in this context of particular scarce resources. It is questionable which criteria can be used in case of inescapable allocation decisions ... -
CT-basierte Radiomic Feature Analyse zur Unterscheidung von malignen und benignen Nierentumoren
(2023-11-10)The renal cell carcinoma is the most common malignant tumor of the kidney, with approximately 15,000 new cases per year in Germany. The incidence of small kidney tumors with often benign characteristics has been increasing ... -
Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii
(2023-11-09)Within the mitochondria of Toxoplasma gondii, 1-hydroxyquinolones were identified as affine inhibitors of the alternative NADH-dehydrogenase at the first complex of the respiratory chain. Another target structure of the ... -
Schwannzell-Remyelinisierung bei Neuromyelitis optica
(2023-11-07)Neuromyelitis optica (NMO) is a chronic, autoimmune inflammatory, astrocyte depleting and demyelinating disease of the central nervous system (CNS) and typically affects the spinal cord (myelitis) and optic nerves (neuritis ... -
Untersuchungen zum Einfluss von Nikotinsäure auf Adipozytenhormone und Entzündungsparameter bei Patienten/Patientinnen mit metabolischem Syndrom
(2023-11-03)The present exploratory descriptive study essentially served the purpose of generating hypotheses. The starting point for the considerations was that the anti-atherosclerotic effect of niacin could be attributed to an ... -
Nachweis von Mikrokalk mittels cone-beam Computertomographie (CBCT) der weiblichen Brust im Vergleich zum Standardverfahren der digitalen Mammographie
(2023-10-11)Digital MG is still used as the primary examination procedure in the context of breast diagnostics, but it has significant limitations, especially in women with high breast density. In addition to the detection of breast ... -
Ehrenamtliche Begleitung von Menschen mit einer nicht-onkologischen Erkrankung am Lebensende
(2023-09-13)Background: Hospice volunteers are important actors in hospice and palliative care. Due to the progressive integration of non-oncological patients, they will be supported more and more by volunteers in the future. The aim ... -
In vitro analyses of CD4-protein function in dedifferentiated keratinocyte cell lines
(2023-09-06)To study the role of the Hedgehog-Patched (Hh/Ptch) signaling pathway in T-cells, the two-step DMBA/TPA carcinogenesis protocol have been applied to mice with an homozygous Ptch depletion in CD4-expressing cell (Ptch ... -
Hungernder Krebs-Evaluation der Kombinationstherapie mit 2-Deoxy-D-Glukose und Metformin beim Endometriumkarzinom
(2023-09-04)In this thesis, several aspects of the tumor metabolism were examined as an approach for antiproliferative therapies. Thereby, it is shown that therapy with metformin and 2-Deoxy-D-Glucose reaches a significant decrease ... -
Inkongruente Bedürfnisbefriedigung bei Suchterkrankten: Ein Vergleich von Menschen mit Alkohol --, Medikamenten und Verhaltenssucht mit gesunden Probanden
(2023-08-22)Both motivational incongruence (INK-G) and depression have been shown to be associated with alcohol dependence and as such a possible target for treatment strategies. Non-substance addictions (NSA) like Internet addiction ... -
Mikro-RNA-Expression bei der Einschlusskörpermyositis
(2023-08-16)The chronic disease inclusion body myositis belongs to the inflammatory myopathies and is the most common in older age. Muscle weakness and atrophy affect the quality of life of patients. Diagnosis can be made on the basis ...