Browsing Human- und Zahnmedizin by Referee "Flügel, Alexander Prof. Dr."
Now showing items 1-20 of 21
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Einfluss ultravioletten und sichtbaren Lichts auf die NET (Neutrophil Extracellular Traps)-Bildung
(2023-02-16)Neutrophil Extracellular Traps (NETs) are produced by neutrophilic granulocytes and consist of decondensed chromatin decorated with antimicrobial peptides. They defend the organism against intruders and are released upon ... -
Role of the glucocorticoid receptor in the development of ulcerative colitis and colorectal carcinoma in a murine model
(2022-08-29)For many decades, glucocorticoids (GCs) have been an essential pillar of the therapy of many inflammatory diseases. The beneficial effects of this class of hormones occur quickly and reliably after administration, although ... -
Der Einfluss von Lithium auf die Bluthirnschrankenintegrität nach zerebraler Ischämie der Maus
(2022-04-08)Lithium wird seit Jahrzehnten bei der Behandlung von bipolaren Affektstörungen, Manie, Depression und Cluster-Kopfschmerz verwendet. Zusätzlich zeigte die Gabe von Lithium auch in einer Vielzahl präklinischer Tierexperimente ... -
The effect of glatiramer acetate on functional properties of B lymphocytes in patients with MS
(2021-11-29)Objective: We examined the effect of glatiramer acetate (GA) on B-cell maturation, differentiation, and antigen presentation in MS patients. Methods: A cross-sectional study of blood samples from 20 GA-treated and 18 ... -
Untersuchung der Rolle von Eotaxin-1 nach ischämischem Schlaganfall im Mausmodell: Neuroprotektion, Neuroregeneration oder destruktiv-proinflammatorische Rolle?
(2021-04-15)Der ischämische Schlaganfall ist eine der häufigsten Todesursachen in der westlichen Welt und führt oftmals zu einer dauerhaften Behinderung mit relevanten sozioökonomischen Konsequenzen. Die kausale Therapie besteht aus ... -
The effect of dimethyl fumarate on phenotype and function of B lymphocytes in MS patients
(2021-04-09)Although the oral agent DMF was approved for the treatment of RRMS in 2014 and demonstrably reduces relapse rates and disability progression, its effect on B cells, which are now thought to be major contributors to disease ... -
Effekt einer Palmitoylethanolamid-Prophylaxe auf alte oder neutropenische Mäuse nach intrazerebraler E. coli-Infektion
(2020-02-19)Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery. The dietary supplement palmitoylethanolamide ...
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Der Einfluss von Interleukin-3 auf die Läsionslast der experimentellen autoimmunen Enzephalomyelitis
(2018-06-01)Multiple sclerosis is an inflammatory disease of the central nervous system. Despite decades of research its etiology remains unclear. Keeping in mind that experimental autoimmune encephalomyelitis is an artificially induced ... -
Immunologische und molekulare Profile von "smoldering lesions" der Multiplen Sklerose
(2017-05-18)Multiple sclerosis (MS) is a chronic-inflammatory disease of the central nervous system. It is characterized by progressive demyelination for which no effective therapy has yet been established. Characteristics of the ... -
Die Funktion von CX3CR1 in einem spontanen Modell der experimentellen Autoimmunenzephalomyelitis
(2016-08-16)Multiple sclerosis is an inflammatory autoimmune disease of the central nervous system. The best method to reflect the clinically and pathologically heterogeneous disease in animal models is an experimental autoimmune ... -
Untersuchungen zur Pathogenese subpialer kortikaler Läsionen bei Multipler Sklerose und bei Marmosetten mit experimenteller autoimmuner Enzephalomyelitis
(2015-06-30)Lately, evidence has accumulated the extensive grey matter involvement in multiple sclerosis (MS). It is known that subpial cortical demyelination (SCD) accounts for the greatest proportion of demyelinated cortex in ... -
Neuartige Wirkmechanismen und Therapiestrategien von Glukokortikoiden in der Behandlung von Multipler Sklerose im Tiermodell
(2014-06-24)Despite the enormous progress being made in the development of new therapies, such as monoclonal antibodies, GCs are still one of the best options available to treat inflammatory diseases. One of the main drawbacks of this ... -
Quantitative Untersuchung der subkortikalen Neurone im Multiple-Sklerose-Modell der experimentellen autoimmunen Enzephalomyelitis bei Callithrix-jacchus-Marmosetten
(2014-01-14)The general aim of this study was to investigate the densitiy of white matter neurons in marmosets with MOG-induced experimental autoimmune encephalomyelitis (EAE). The specific aim was to see whether there was an increase ... -
Quantitative Untersuchung der Oligodendrozytendichte im Kortex von Callithrix-jacchus Marmosetten mit Experimenteller Autoimmuner Enzephalomyelitis
(2013-11-01)Histopathological studies of Multiple sclerosis (MS) are usually limited by the fact that autopsy tissue is usually from patients in the chronic stage of the disease. Thus far there are only few results on the pathology ... -
Beeinflussung des Verlaufs von ZNS-Infektionen in immundefizienten Mäusen durch Immunstimulanzien
(2013-10-30)Escherichia coli is the leading cause of Gram-negative meningitis in infants and can also cause meningitis and meningoencephalitis in old and immunocompromised patients. In this doctoral thesis we studied the contribution ... -
Das lymphozytäre Entzündungsinfiltrat in Multiple-Sklerose-Läsionen: Immunhistochemische Analyse im Bezug auf immunopathogenetische Subtypen und Läsionsaktivitäten
(2012-06-21)Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS. The heterogeneity of the disease is reflected in different immunopathological patterns. Aim of the study is the examination of lymphocytes ... -
Die Magnetresonanztomographie im Therapiemonitoring liposomaler Glukokortikosteroide in zwei Tiermodellen der Multiplen Sklerose unter Berücksichtigung von Läsions- und Seitenventrikelgröße sowie Liquorsignalintensität
(2012-03-16)The efficacy of liposomal glucocorticosteroids is examined in two animal models of multiple sclerosis by quantitative evaluation of T2-weighted magnetic resonance imaging. Furthermore the ... -
Vergleichende Analyse der Wirksamkeit synthetischer Glukokortikoide sowie des Wirkmechanismus von Liposomen-verpackten Kortikosteroiden bei der Therapie der Experimentellen Autoimmunen Enzephalitis (EAE) unter Berücksichtigung systemischer Nebenwirkungen
(2011-07-18)Glucocorticoids (GC) are widely used to treat acute relapses of multiple sclerosis patients. By comparison of diverse GC in the treatment of experimental autoimmune encephalomyelitis (EAE) ... -
Multiple Sklerose und Dopamin-Rezeptoren
(2011-04-13)Is there a link between the dopamine system and multiple sclerosis? The cause for multiple sclerosis (MS), an important neuroimmunological disease, is currently not known. Lesions ... -
Analyse transgener Mauslinien mit zelltypspezifischer Expression fluoreszenter Proteine als Modelle für akute Hirntraumata
(2010-10-12)Within the thesis presented in here two mouse lines (PRDA & PRDB) were characterized. In these lines the fluorescent protein DsRed was expressed under the control of the PLP promotor. Both ...