Browsing Human- und Zahnmedizin by Referee "Ghadimi, Michael Prof. Dr."
Now showing items 1-12 of 12
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Zeitabhängige Prädiktoren für postoperative Wundinfektion nach Acetabulumfraktur
(2024-08-06)Acetabular fractures represent a surgical challenge. Heterogeneous as the fracture pattern, patient characteristics and the range of complications regularly require regularly require individual solutions. Surgical wound ... -
Auswirkungen eines geführten perioperativen Behandlungskonzeptes bei ambulant zu operierenden Kindern auf die prä- und postoperative Befindlichkeit
(2021-02-25)In this retrospective analysis, parents of a total of 100 children between 1 and 12 years old were contacted between October 2015 and September 2016. All children underwent outpatient surgery at the department of general, ... -
Lokoregionäre Therapie kolorektaler Lebermetastasen im Rattenmodell: Immunhistochemische Differenzierung von DNA und Hypoxie induzierten Schäden nach Applikation von Embolisatpartikeln
(2020-03-31)About 60.000 patients are diagnosed with colorectal cancer (CRC) in Germany each year. Fifty percent of these patients develop colorectal liver metastases (CRLM) during the course of the disease. The surgical resection ... -
Die Rolle von CBP bei der Strahlenresistenzentwicklung im kolorektalen Karzinom
(2019-07-22)This thesis focuses on the protein CBP (CREB-binding protein) in colorectal cancer. CBP is a histone acetyltransferase with 4 transactivation domains and acetylates a wide variety of proteins. CBP is a multifunctional ... -
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
(2014-09-25)A considerable percentage of rectal cancers are resistant to standard preoperative chemoradiotherapy. Because patients with a priori-resistant tumors do not benefit from multimodal treatment, understanding and overcoming ... -
Exploration medizinethischer Implikationen individualisierter Medizin beim lokal fortgeschrittenen Rektumkarzinom aus Sicht von Ärzten und Forschern - eine empirisch-ethische Untersuchung
(2014-06-30)So-called individualized medicine is an emerging concept in clinical research and clinical practice. We conducted a social-empirical interview study with members of a leading German clinical research group (KFO 179) about ... -
Der Einfluss von NR3C1 und PDK4 auf das Wachstum kolorektaler Tumorzellen
(2012-09-12)Colorectal cancer originates from normal mucosa cells as a result of genetic alterations that cause changes in their differentiation status and in the control of cell growth. Understanding the molecular mechanisms of ... -
KRAS und BRAF Mutationen im lokal fortgeschrittenen Rektumkarzinom
(2012-06-05)The aim of this study was to analyse mutations in BRAF and KRAS in locally advanced rectal cancer. For the first time, pretherapeutic biopsy were used to determine the mutation status. In the analysis no V600E mutations ... -
Klinischer Stellenwert der [<sup>18</sup>F]Fluor-2'-Deoxyglukose-Positronenemissionstomografie ([<sup>18</sup>F]FDG-PET) in der präoperativen und postoperativen Situation bei Patienten mit R0-resezierten Lebermetastasen eines kolorektalen Karzinoms
(2011-10-31)AIM: The aim of the study was the evaluation of the clinical value of [18F]FDG-PET in the pre- and postoperative assessment of patients after R0-resection of CEA-expressing colorectal ... -
Applikation der Comparativen Genomischen Hybridisierung (CGH) zur Vorhersage des Ansprechens von Rektumkarzinomen auf neoadjuvante Radiochemotherapie
(2011-10-12)Introduction - Standard treatment of rectal cancer patients in UICC stages II and III comprises preoperative chemoradiotherapy followed by radical surgery. But there is a wide spectrum of ... -
In-vitro-Untersuchungen zu transkriptionellen und translationalen Zusammenhängen von COX2 und MUC4 im Pankreaskarzinom
(2011-06-23)Pancreatic Cancer is characterized by an aggressive tumor biology with early metastasation, limited treatment modalities and a poor prognosis. In the last years various molecules have been ... -
Quantitative Proteinexpressionsanalysen in den klinisch-pathologischen Subtypen Gastrointestinaler Stromatumoren (GIST)
(2011-02-22)Aims: Gastrointestinal stromal tumors (GIST) belong to the most common mesenchymal gastrointestinal neoplasms (70%). The different clinical outcome depends on clinical-pathological ...