Dokumente Human- und Zahnmedizin nach Gutachter "Groß, Uwe Prof. Dr."
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Korrelation der 5-Flucytosin-Resistenz in Candida albicans mit Markerpeak im MALDI-Massenspektrum durch neue Extraktionsmethode
(2024-03-06)Candida albicans is a facultative pathogenic fungus that occurs worldwide and is found in the gastrointestinal tract of the majority of people. In immunocompromised patients, however, it can lead to severe systemic infections. ... -
Verbesserung der MALDI-TOF-basierten Identifizierung humanpathogener Pilze durch die Erstellung individueller Datenbanken
(2023-12-12)The identification of rare fungal species using MALDI-TOF mass spectrometry is limited by the fact that commercial databases are incomplete or the preparation protocols in routine diagnostics are complex. This dissertation, ... -
Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii
(2023-11-09)Within the mitochondria of Toxoplasma gondii, 1-hydroxyquinolones were identified as affine inhibitors of the alternative NADH-dehydrogenase at the first complex of the respiratory chain. Another target structure of the ... -
Effekt der Carbapenemasen Vim1, Ndm1 und Oxa48 auf die bakterielle Fitness von E. coli K12 MG1655
(2022-09-14)Antibiotic resistance is an important subject in clinic medicine. As part of this doctor's thesis, the effect of three different Carbapenemases Vim1, Ndm1 and Oxa48 on bacterial fitness of E. coli bacteria was examined. ... -
Analyse der antiviralen Aktivität von IFITM-Proteinen
(2022-07-19)Viral infections are among the leading causes of death worldwide. Only a limited number of therapy options are available. Moreover, the high mutation rate of many viruses leads to the rapid development of resistance. In ... -
Entwicklung MALDI-TOF-basierter diagnostischer Methoden zur Identifikation periprothetischer bzw. gelenkassoziierter Infektionen
(2022-07-11)Development MALDI-TOF based diagnostic methods to detect periprothetic or joint associated infections -
COVID-19 - Evaluation von Biomarkern im klinischen Verlauf der Erkrankung
(2022-03-22)The course of serological and laboratory biomarkers during the phase of inpatient treatment of COVID-19 patients was investigated. Data from a total of n=47 patients were retrospectively analyzed. These included selected ... -
Das Wachstums- und Sporulationsverhalten klinischer Clostridioides-difficile-Isolate unter intestinalen Gallensalzkonzentrationen
(2021-11-10)Problem: Clostridioides difficile infections (CDI) have emerged as the leading cause of hospital-acquired diarrhea. The disruption of physiological gut microbiota by consumption of antibiotics is one of the major risk ... -
Zusammensetzung der mikrobiellen Flora auf der Zunge und im Speichel bei frühkindlicher Karies
(2020-09-22)Early childhood caries is still a worldwide problem that affects children in developing countries as well as children in industrialized nations such as Germany. It is a multifactorial disease, where the main factors are ... -
Epidemiology and prevalence of oral candidiasis in HIV patients from Chad
(2016-03-03)The study was performed to determine the prevalence and epidemiology of oral candidiasis among HIV-positive patients in Chad and evaluate the susceptibility of the yeasts found in the oral cavity to five antifungals. The ... -
Das Konzept der Vulnerabilität im Kontext transnationaler Biomedizin
(2015-05-12)Background & aim: Transnational medical research has increased tremendously in the past years. While this is an important part of globalization and internationalization of science and health care, it also raises questions ... -
Establishment of a clinical algorithm for the diagnosis of P. falciparum malaria in children from an endemic area using a Classification and Regression Tree (CART) model
(2015-01-20)For the year 2009, the World Health Organization (WHO) estimated 225 million cases of malaria worldwide. Fifty-eight percent of all deaths on the African continent due to malaria were children under 5 years of age. As ... -
Epidemiologie Virulenz-assoziierter Markergene in Campylobacter jejuni-Subpopulationen
(2014-10-01)Thermophilic C. jejuni is one of the most common causes of bacterial gastroenteritis in humans worldwide. The pathogen is transmitted mainly through cross-contaminated food, mostly originating from poultry products. C. ... -
Transcriptional regulation of sex-dependently expressed renal organic anion transporter 1 and 3
(2013-02-11)The renal organic anion transporters (OATs) play a pivotal role in the elimination of endogenous and exogenous substrates. In rats, an often used preclinical animal model, the basolateral located organic anion transporter ... -
Zur Bedeutung von Plasmiden für die Pathogenität von Campylobacter jejuni
(2012-11-08)Campylobacter jejuni is one of the most common causes of bacterial diarrhoe in humans. We examined the influence of plasmids in the ability of isogenic bacterial strains of C.jejuni to infect intestinal human caco2-cells ... -
Vergleichende epidemiologische Untersuchungen zur bakteriellen Genese von Fieber unklarer Ursache in Ghana
(2012-05-29)Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections in rural hospitals in Ghana. In 2001–2002 and in 2009, Salmonella enterica serovar Typhi was the ... -
Optimierung der molekularbiologischen Diagnostik systemischer Mykosen
(2012-05-15)The rapid and efficient diagnosis of systemic fungal infections is essential for an effective therapeutic regimen of frequent immunosuppressed patient population. For this purpose, the PCR method offers a good diagnostic ... -
Assoziation von Genvarianten aus der Chromosomenregion 5q31-33 mit der Inzidenz von Malaria und Anämie bei Kindern aus Ghana
(2011-11-17)In this work, the 5q31-33 chromosomal region was investigated for genetic associations with the incidence of malaria and anemia in children from Ghana.Variants of the genes interleukin 4 ... -
Estimating Chronic Wasting Disease infectivity in cell culture
(2011-11-14)The rapid spread and high prevalence of CWD in North American cervids have raised concerns about a potential risk to human health. Experimental transmission of CWD to various species has ... -
Stamm- und wirtszellabhängige Apoptose-Induktion durch Campylobacter jejuni
(2011-11-04)At present Campylobacter jejuni is the numerically most important pathogenic agent of enteritis in Germany. The suspected main toxin of the organism is the Cytolethal distending toxin (Cdt), ...