Dokumente Human- und Zahnmedizin nach Gutachter "Haase, Detlef Prof. Dr."
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Genetische Varianten von PPM1D und TP53 bei Patienten mit myelodysplastischen Syndromen und komplex-aberranten Karyotypen
(2023-02-07)Myelodysplastic syndromes (MDS) are a heterogenous group of clonal bone marrow diseases leading to ineffective hematopoiesis. In over 90% cyto- and molecular genetic aberrations can be detected with complex aberrations ... -
Einfluss von YAP auf die Invasion von mesenchymal transformierten Tumorzellen
(2021-01-13)Breast cancer is the most common cancer in women worldwide. In the metastatic stage, breast cancer is no longer curable and mortality is high. Therefore, research into the metastatic pathways and ways of influencing them ... -
Wiederholte Anti-CEA-Radioimmuntherapie mit 131I-Labetuzumab nach Resektion kolorektaler Lebermetastasen - Ergebnisse einer monozentrischen Phase I/II-Studie
(2018-03-19)Background: A previous phase-I/-II trial has shown that a single administration of anti-CEA 131iodine(I)-Labetuzumab as a radioimmunotherapy (RAIT) after resection of colorectal liver metastases (CRC-LM) was well-tolerated ... -
In-vitro-Studie zum Einfluss verschiedener Immunsuppressiva auf Gesamt- und Lebendzellzahl, Zelldurchmesser und Menge an Prokollagen Typ I gingivaler Fibroblasten
(2017-06-07)Due to the decreasing number of organ transplants, their tolerability gains greater significance for affected patients. Therefore, these patients are permanently depended on taking immunosuppressive drugs, which have ... -
Einfluss von Risikofaktoren, Umständen der Diagnosestellung und Früherkennungsmaßnahmen auf die Tumordicke nach Breslow bei Patienten mit malignem Melanom
(2016-08-04)The malignant melanoma is a common type of cancer which has a good prognosis if detected early. This doctoral dissertation examines whether certain risk factors influence the depth of the tumor and therefore the prognosis ... -
Klinische und molekularzytogenetische Charakterisierung von Tumoren der Pinealisregion
(2013-11-22)Tumors of the pineal region (PR) are rare. They constitute for only 1% of tumors in adulthood. Unspecific clinical symptoms frustrate an early diagnosis in PR tumors and imaging studies can be suggestive of the type of ... -
Zytogenetische Charakterisierung der Glioblastomzelllinie G112 in Bezug auf tumorstammzellähnliche Eigenschaften und Strahlentherapie
(2013-01-09)The glioblastoma multiforme (GBM) is the most frequent and the most malignant brain tumor showing the highest rate of anaplasia (WHO Grade IV) (Riede and Schaefer 2001b). The prognosis is bad (Mueller 2006) despite ... -
Mikrosatelliteninstabilität (MSI) in Rektumkarzinomen vor und nach Chemoradiotherapie
(2012-05-16)Colorectal carcinomas are the second most common cancers in Germany. Spontaneously occurred gene damages as well as hereditary acquired gene damages may cause cancer. Analyses for MSI are performed as standard in the ... -
Progenitorzelleigenschaften bei myelodysplastischen Syndromen (MDS) mit Eisenüberladung
(2011-10-07)In patients with myelodysplastic syndromes (MDS) iron overload caused by long term red blood cell transfusions is an important factor for comorbity. In this report we present the results ... -
Vergleich Gastrointestinaler Stromatumoren (GIST) mit Exon-11-Punktmutationen und Exon-11-Deletionen nach klinisch-pathologischen Parametern und Lokalisation
(2011-03-02)Vergleich Gastrointestinaler Stromatumoren (GIST) mit Exon-11-Punktmutationen und Exon-11-Deletionen nach klinisch-pathologischen Parametern und Lokalisation -
Polymorphismen der Glutathion-S-Transferase A1 in Zusammenhang mit malignen hämatologischen Erkrankungen
(2010-08-20)Since a long time xenobiotic metabolizing enzymes are an object of investigation. There are a series of polymorphisms described which are associated with a high susceptibility to develop ...