Browsing Human- und Zahnmedizin by Referee "Liersch, Torsten PD Dr."
Now showing items 1-7 of 7
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Die Bedeutung der Thymidinphosphorylase bei Patienten mit lokal fortgeschrittenem Rektumkarzinom (UICC-Stadium-II/-III) im Kontext einer 5-FU basierten multimodalen Therapie
(2014-06-19)Thymidine phosphorylase (TP) is an enzyme, which is involved in the physiological metabolism of each cell. There it acts as an angiogenic factor, but further catalyzes at least three known reactions, which are related to ... -
Der HER-2-Status im lokal fortgeschrittenen Rektumkarzinom: Positivitätsrate, mögliche prädiktive und prognostische Bedeutung
(2013-08-26)In patients with advanced rectal cancer (cUICC II and III) multimodality therapy resulted in better long-term local tumor control. Ongoing clinical trials are focusing on therapy intensification to improve disease-free ... -
Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen
(2013-01-23)Gene polymophisms could play an important role in the variability of therapy response in gemcitabine treated patients with pancreatic carcinoma. The retrospective study showed that a polymorphism in ENT-1, a carrier of ... -
Molekularzytogenetische Veränderungen bei kolorektalen Karzinomen und Lebermetastasen kolorektaler Karzinome
(2012-11-05)Colorectal carcinoma (CRC) is one of the most common malignant neoplasms in Germany. Most patients die due to metastases, whereas the liver is the most affected metastatic site. Nowadays scientists use molecularcytogenetic ... -
Die perioperative Chemotherapie des lokal fortgeschrittenen Magenkarzinoms nach Göttinger Erfahrung
(2012-06-08)Background Recent studies demonstrated an improved outcome of patients with resectable adenocarcinoma of the stomach treated with a perioperative chemotherapy compared with surgery alone. Besides, a maximum number of ... -
Oxidativer Stress als Biomarker für die (Neben-) Wirkungen von Strahlentherapie: Bestimmung von Isoprostanspiegeln und Genexpressionsprofilen in Patientenproben
(2011-11-14)Radiotherapy is used to treat prostate cancer as well as locally advanced rectal cancer within a preoperative chemoradiotherapy. To understand the causal relationship between the effect of ... -
Prädiktives und prognostisches Potential der Thymidylatsynthase als Biomarker im multimodalen Therapiekonzept 5-FU-basierter Radiochemotherapie des lokal fortgeschrittenen Rektumkarzinoms
(2010-11-15)Purpose 5-Fluorouracil remains the backbone of radiochemotherapy (RCT) of locally advanced rectal cancer. Its main target thymidylate synthase (TS) is speculated to be an important ...