Dokumente Human- und Zahnmedizin nach Gutachter "Müller, Michael Prof. Dr."
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Behavioral and electrophysiological assessment of hearing function in mice with deficient sound encoding at inner hair cell ribbon synapse
(2023-03-10)Auditory synaptopathy in humans is characterized by poor speech perception especially in noisy environments despite of preserved active cochlear amplification. The ABR of affected patients is absent or shows a significant ... -
Oxidative stress in the pathogenesis of renal injury: the effect of the antioxidant danshensu on renal fibrosis
(2022-11-29)Chronic kidney disease (CKD), often manifested in its end-stage as renal fibrosis, is a widespread illness, for example in children following congenital urinary obstruction and in adults due to an increasing number of ... -
Spreading Depression induzierte Redoxveränderungen in hippokampalen Neuronen der Maus
(2022-08-03)Spreading depression (SD) is a neurological phenomenon characterized by massive neuronal and glial depolarization that slowly spreads in brain tissue at rates of several millimeters per minute. Due to the almost complete ... -
Einfluss der Rett-Syndrom-assoziierten MeCP2-Defizienz auf die DNA-Oxidation, strukturelle und inflammatorische Marker in zerebralem Gewebe
(2021-11-26)Rett-Syndrome is a disorder with impaired neuronal development, in which mutations in the MECP2 gene lead to severe motor and cognitive impairment. Part of a complex clinical appearance are a disturbed cardiorespiratory ... -
Charakterisierung von Peroxiredoxin 2 im zentralen Nervensystem bei Multipler Sklerose
(2021-10-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, characterized by demyelination and axonal damage as well as neuronal degeneration. Oxygen-derived free radicals are an important ... -
Therapeutischer Nutzen einer mitochondrialen Katalase-Expression in einem Mausmodell des Rett-Syndroms
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that mainly affects girls with a prevalence of 1: 10,000 to 1: 15,000. The clinical symptoms are complex and are characterized by cognitive impairment, irregular ... -
Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Evaluierung einer oralen Antioxidantien-Therapie in einem Mausmodell für das Rett-Syndrom
(2021-09-06)Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by spontaneous mutations in the X-chromosomal gene MECP2 encoding methyl-CpG binding protein 2 (MeCP2). Affecting almost exclusively females, it causes ... -
Untersuchungen zur neuromuskulären Pathophysiologie bei der Charcot-Marie-Tooth-Typ-1A-Erkrankung
(2021-05-17)Charcot-Marie-Tooth type 1A Disease is the most common hereditary neuropathy with actually no causal treatment. The thesis evaluates whether the high-density surface electromyography (Multi-Unit-sEMG) with recording of 64 ... -
Live-Imaging von Kalzium-induzierter axonaler Degeneration in transgenen Mausmodellen des Morbus Parkinson
(2020-07-28)Introduction: In Parkinson’s Disease (PD), damage to axonal terminals precedes the loss of somata, which follows later in a “dying-back” pattern (axonal degeneration). The protein alpha-synuclein (aSyn) and its mutant forms ... -
Evaluation des Antwortverhaltens des genetisch kodierten optischen Redox-Indikators HyPer
(2020-07-07)Oxygen radicals, also known as reactive oxygen species (ROS), play a significant role in neurological diseases and in cell communication. Therefore, there is a tremendous interest in monitoring (sub)cellular redox conditions. ... -
Experimental therapy with progesterone on a mouse model for hereditary neuropathy with liability to pressure palsies (HNPP)
(2020-02-26)Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant demyelinating disorder characterized by episodic, recurrent peripheral sensory and motor neuropathies, triggered by minor traumas or ... -
Mitochondriale Redoxhomöostase in hippocampalen Neuronen MeCP2-defizienter Mäuse
(2019-09-11)This work should address the question of whether mitochondrially-generated ROS are the possible cause of neuronal dysfunction in RTT. Data collected in previous studies suggest that oxidative stress is important for the ... -
Untersuchung des Einflusses der LTD-artigen motorkortikalen Plastizität auf die interhemisphärische Konnektivität bei Patienten mit einer Schizophrenie
(2018-03-20)Post-mortem and in vivo studies provide evidence for a link between reduced plasticity and dysconnectivity in schizophrenia patients. It has been suggested that the association between plasticity and connectivity contributes ... -
Transgene Redoxindikator-Mäuse mit mitochondrialer roGFP1-Expression: Phänotypisierung, neuronales Verteilungsmuster und Sensorfunktionalität
(2017-12-05)Reactive oxygen spezies (ROS) and redox alterations determine not only physiological signaling but also lead to oxidative stress, cellular dysfunction and a wide range of pathologies. A major source of ROS-generation is ... -
Einfluss des Dopamin-1 Rezeptor-Subtyps auf inhibitorische Neuroplastizität am Modell des motorischen Kortex des Menschen
(2017-05-22)The neuromodulator Dopamine improves in both animal and human experiments learning and memory formation. The proposed mechanism behind the positive effects of Dopamine on cognition is a focusing effect on neuroplasticity. ... -
Therapeutischer Einfluss des Radikalfängers Trolox in einem Mausmodell für das Rett-Syndrom: Bewertung oxidativer Stressmarker in zerebralem Gewebe
(2017-05-10)The aim of this work was to assess a variety of phenotypic and biochemical features in a mouse model of Rett-syndrome, which was treated in vivo with the free radical scavenger Trolox. Rett-syndrome is a postnatal progressive ... -
Analyse funktioneller und struktureller Mitochondrienveränderungen in einem Maus-Modell für das Rett-Syndrom mittels 2-Photonen-Mikroskopie
(2017-01-09)Rett syndrome is a neurodevelopmental disorder that is caused by de novo mutations in the X-chromosomal MECP2 gene which encodes for the transcriptional modulator methyl CpG binding protein 2 (MeCP2). Almost girls are being ... -
Einfluss des zellulären Prion-Proteins auf die LDH-Expression unter oxidativen Stressbedingungen
(2015-11-09)Although a physiological function of the cellular prion protein (PrPc) is still not fully clarified, a PrPc-mediated neuroprotection against hypoxic/ischemic insult is intriguing. After ischemic stroke prion protein ... -
Charakterisierung eines transgenen Mausmodells mit spezifischer zytosolischer Expression des optischen Redox-Indikators roGFP1 in Neuronen
(2015-09-04)Cellular redox alterations and reactive oxygen species (ROS) contribute to biochemical pathways and cellular signaling, but do also play a critical role in the development of neurodegenerative as well as neuropathological ...