Browsing Human- und Zahnmedizin by Referee "Pieler, Tomas Prof. Dr."
Now showing items 1-9 of 9
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Konstitutive Protein-Protein-Interaktionen regulieren die Aktivität der Bruton-Tyrosin-Kinase in B-Zellen
(2017-05-17)Protein tyrosine kinase Btk is a crucial effector for the ITAM dependent B-cell antigen receptor (BCR) signaling pathway. Its absence or dysfunction leeds to X-linked agammaglobulinaemia (XLA) in humans. Phosphorylation-dependent ... -
miR-125 regulates niche organization in Drosophila melanogaster ovary by affecting Notch signaling pathway via its target Tom
(2015-08-11)For the maintenance of tissue homeostasis upon injury or natural cell turnover, a constant source of new cells is needed. Usually these cells are delivered by tissue specific adult stem cells. ... -
Regulation der „spleen tyrosine kinase“ Syk im B-Zell-Antigen-Rezeptor-Signalweg
(2013-11-25)The “spleen tyrosine kinase” Syk offers transducer functions for a number of ITAM-based immune cell receptors and is critical for the development and activation of B lymphocytes. Furthermore Syk has been implicated in the ... -
Studies on adaptor proteins that shape antigen receptor-proximal signal transduction in B lymphocytes
(2011-08-15)Signals that are transduced by the B cell antigen receptor (BCR) control B cell development and activation. Engagement of the BCR initiates the assembly and activation of the antigen ... -
Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens
(2011-04-14)Key factors known to be involved in the foundation of the mammalian germ cell lineage have been described in the mouse only. To find mechanisms applicable to all mammals we analysed the ... -
Induktion und Differenzierung der proepikardialen Serosa: Analyse einer Vorläuferzellpopulation des embryonalen Herzens
(2007-11-12)The proepicardium is an embryonic precursor cell population, which delivers the epicardium, the cardiac interstitium and all cells of the coronary blood vessels. The proepicardium consists ... -
Analysen zum nukleozytoplasmatischen Transport von Regulatorproteinen des circadianen Rhythmus
(2004-08-04)The circadian rhythm is driven by an endogenous biological clock that regulate many biochemical and physiological processes with a 24h periodicity. A conserved set of genes define a ... -
Molekulare Analyse eines Homöobox-Gen-Promotors in der Gehirnanlage von Wirbeltierembryonen
(2002-12-09)The ANF homeobox genes belong to the earliest group of genes expressed in the vertebrate anterior central nervous system. Targeted disruption of the murine ortholog Hesx1 reveals morphological ... -
Identifizierung und funktionelle Charakterisierung von vegetal lokalisierten RNAs in der Xenopus laevis Oozyte
(2002-08-28)The subcellular localization of mRNA molecules is an important mechanism for regulating gene expression at the post-transcriptional level. In Xenopus laevis oocytes, vegetally localized ...