Dokumente Human- und Zahnmedizin nach Gutachter "Rizzoli, Silvio Prof. Dr."
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Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Zur Rolle des homodimeren Erythropoietin-Rezeptors für erythropoietininduzierte Neurogenese und kognitive Funktionen im Mausmodell
(2022-06-13)Cognitive dysfunction and decline are clinical hallmarks of neurodegenerative brain diseases and yet await sufficient therapy. Proven in numerous clinical studies, erythropoietin, named after its function in stimulating ... -
Expansionsmikroskopie des Rattenhirns zur subzellulären Lokalisation synaptischer Proteine
(2022-01-26)The basis and drive for the implementation of the present work was the desire for a more precise understanding of the subcellular distribution and quantity of presynaptic proteins in presynapses of different brain regions. ... -
Charakterisierung des Targetingverhaltens präsynaptischer Proteine
(2018-04-24)Studying features of proteins can be done by expressing recombinant versions of those proteins in a cellular environment which facilitates correct transport and distribution. Here this model was used to study features ... -
Synaptic Vesicles, Mitochondria, and Actin Alterations in SMN-deficient Mice
(2015-05-22)Proximal spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of the second motor neurons and progressive paralysis with atrophy of the proximal muscles. After cystic fibrosis, SMA ... -
Neuroligin-4: Einfluss auf die synaptische Übertragung exzitatorischer Neurone der Schicht IV des Barrel-Kortex
(2013-11-19)Neuroligins (NL) are predominant postsynaptically localized transmembrane adhesion molecules that interact with the presynaptically localized protein neurexin. There are different NL-isoproteins (NL 1 – NL 4) that differ ... -
Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell
(2013-01-24)During the process of myelination in vertebrates axons are spirally ensheathed by the oligodendroglial plasma membrane. This ensheathment consists of a highly specialized membrane with a distinct protein and especially ...