Dokumente Human- und Zahnmedizin nach Gutachter "Sereda, Michael Werner Prof. Dr."
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Identifizierung von In-vivo Interaktionspartnern von PMP22 im peripheren Nerven der Ratte
(2023-03-20)The most common hereditary neuropathy, Charcot-Marie-Tooth disease type 1A (CMT1A), is caused by a duplication of the gene coding for the peripheral myelin protein 22 (PMP22). Despite long lasting scientific investigations, ... -
Biologische Mechanismen und pharmakologische Induzierbarkeit von translationalem Readthrough
(2021-12-06)Termination of translation is mediated when the A-site of the ribosome reaches a stop codon and release factors interact with the stop codon. Due to the competition between release factors and near-cognate tRNAs a stop ... -
Die Effekte des Wlds-Gens und der Gabe von Nikotinamid auf akute und chronisch-sekundäre Axon-Degeneration
(2021-07-21)Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy and a duplication of the peripheral myelin protein of 22 kDa (PMP22) gene causes the most frequent subform CMT1A. Clinical impairments are determined ... -
Experimental therapy with progesterone on a mouse model for hereditary neuropathy with liability to pressure palsies (HNPP)
(2020-02-26)Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant demyelinating disorder characterized by episodic, recurrent peripheral sensory and motor neuropathies, triggered by minor traumas or ... -
Einfluss der Rho-Kinase-Hemmung auf Mikrogliazellen im SOD1-G93A-Mausmodell der Amyotrophen Lateralsklerose
(2017-06-20)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by a combined degeneration of the first and second motoneuron and their axons, accompanied by consecutive muscle weakening and physical ... -
Auswirkungen des PPARγ-Agonisten Pioglitazon auf Peroxisomen des Gehirns im X-ALD-Mausmodell
(2017-06-13)X-linked adrenoleukodystrophy is a metabolic genetic disorder caused by inactivation of the peroxisomal ABCD1 transporter of very long chain fatty acids (VLCFs). It is characterized by progressive demyelination within the ... -
Experimentelle Therapie eines transgenen Tiermodells der Charcot-Marie-Tooth-Krankheit mit Meriva-Curcumin und Cholesterol
(2017-06-06)The charcot marie tooth disease is the most frequent type of hereditary myelinating disorders of the peripheral nervous system in the human race. Caused by a myelin gene duplication of the PMP22-Gen, the expression level ... -
Effekte der präsymptomatischen Applikation der Rho-Kinase-Inhibitoren Fasudil und Y-27632 im SOD1-(G93A)-Mausmodell der Amyotrophen Lateralsklerose
(2017-02-20)This study demonstrates the successful pre-clinical testing of a new pharmacological approach in the treatment of amyotrophic lateral sclerosis using Rho-kinase-(ROCK)-inhibition. The Rho/ROCK signal cascade represents an ... -
Pharmakologische Inhibition von Rho-Kinase im Mausmodell der Amyotrophen Lateralsklerose
(2015-06-12)Since the development of Riluzol no substance, which had been successfully tested in a preclinical setting before, has been able to be successful as a disease modifying drug in human ALS although there has been enormous ... -
Analyse des PPAR-a-Liganden Fenofibrat auf die ABCD1-defiziente Maus
(2014-07-08)The X-linked adrenoleukodystrophy is a peroxisomal hereditary metabolic disease that is due to the loss of function of the peroxisomal transmembrane transporter ABCD1. We distinguish between the frequent progressive forms ... -
Charakterisierung der Skelettmuskelregeneration im Mausmodell der Einschlusskörpermyositis
(2014-05-26)The inclusion body myositis is the most common acquired myopathy in patients over 50 years. The pathogenesis is not well known. Besides of degenerative and inflammatory mechanisms, an alteration in the regeneration capicity ... -
Tierexperimentelle Behandlungsversuche der Charcot-Marie-Tooth-Erkrankung 1A
(2014-02-27)Charcot-Marie-Tooth Disease is the most common inherited demyelinating neuropathy of the peripheral nervous system. The most frequent subform is caused by an intrachromosomal du-plication, leading to toxic overexpression ... -
Die Rolle der Rezeptor-Protein-Tyrosin-Phosphatase Typ ζ bei der De- und Remyelinisierung
(2013-10-11)Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by disruption of the blood-brain barrier, inflammation, demyelination, loss of oligodendrocytes, axonal damage and ... -
Der Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystem
(2013-09-05)The peripheral nervous system demonstrates an exceptional plasticity after nerve injury and Schwann cells remyelinate newly regenerated axons. However, myelin sheath thickness does not reach its original thickness and axons ...