Dokumente Human- und Zahnmedizin nach Gutachter "Simons, Mikael Prof. Dr."
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Konditionale Inaktivierung von Pten in einem neuen Mausmodell für tomaculöse Neuropathien
(2017-01-30)Schwann cells in the peripheral nervous system form the myelin sheath by wrapping multiple membrane layers around axons with a diameter greater than 1 μm. Such ensheathment of the axon is considered an important prerequisite ... -
Roles of bHLH Transcription Factors Neurod1, Neurod2 and Neurod6 in Cerebral Cortex Development and Commissure Formation.
(2016-04-07)Basic helix-loop-helix (bHLH) proteins constitute a diverse group of evolutionary well-conserved transcription factors. Many transactivating bHLH proteins follow cell type- or tissue-specific expression patterns and act ... -
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis
(2014-01-21)Recent studies have shown a decrease in annualized relapse rates (ARRs) in placebo groups of randomized controlled trials (RCTs) in relapsing multiple sclerosis (RMS). This dissertation aimed to describe this trend ... -
Der Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystem
(2013-09-05)The peripheral nervous system demonstrates an exceptional plasticity after nerve injury and Schwann cells remyelinate newly regenerated axons. However, myelin sheath thickness does not reach its original thickness and axons ... -
Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell
(2013-01-24)During the process of myelination in vertebrates axons are spirally ensheathed by the oligodendroglial plasma membrane. This ensheathment consists of a highly specialized membrane with a distinct protein and especially ... -
Zur Resistenzentwicklung von Zellen der chronischen myeloischen Leukämie gegenüber Tyrosinkinase-Inhibitoren: Regulation und Funktion des ABC-Transporters A3
(2013-01-03)Inhibition of the BCR-ABL tyrosine kinase activity by the specific tyrosine kinase inhibitors (TKI) imatinib, nilotinib and dasatinib leads to complete remission of the disease in most patients with chronic myeloid ... -
Role of amyloid beta protein modulation in Alzheimer's disease
(2012-07-17)Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. It is mainly characterized by the deposition of amyloid plaques and neurofibrillary tangles. In addition, inflammatory processes in ... -
De - und Remyelinisierung in Dopaminrezeptor-defizienten Mäusen
(2012-05-31)De-and remyelination in dopamine receptor-deficient mice Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous-system with destruction of myelin sheaths, axonal damage and only ... -
UNtersuchung der unterschiedlichen Funktion des Neuregulin-1 im Hinblick auf die Myelinisierung des peripheren und zentralen Nervensystems
(2012-05-14)Understanding the control of myelin formation by oligodendrocytes is essential for treating demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS. It is ... -
Stickoxidmetabolite als Ursache einer differentiellen Myelingenexpression in MS-Läsionen?
(2011-10-18)Nitric oxide metabolites: the cause of dysregulation of myelin protein genes in multiple sclerosis lesions? Actively demyelinating multiple sclerosis lesions are histologically characterized ... -
Establishment of a novel technique to study G protein-coupled receptor activation
(2011-08-17)G protein-coupled receptors (GPCRs) constitute the largest receptor family in mammals and represent important drug targets. Signaling through GPCRs mediates physiological effects that are ... -
Myelinisierung des peripheren Nervensystems in Endothelin-Rezeptor-B-defizienten Ratten
(2011-07-19)Pluripotent stem cells of the neural crest differentiate during the embryonic development in melanocytes, enteric ganglia, craniofacial bone and cartilage cells, as well as peripheral nervous ... -
Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
(2011-02-11)Exosomes are small vesicles of 50-100 nm diameter that derive from intraluminal vesicles (ILVs) and are secreted into the extracellular environment upon fusion of multiversicular bodies ... -
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
(2011-01-27)Oligodendrocytes are the myelin forming cells of the central nervous system. These cells synthesize vast amounts of membrane during the active phase of myelination. In addition, membrane ... -
Charakterisierung der subzellulären Lokalisation von Myelinproteinen in der Shiverer-Maus.
(2010-07-05)As dysmyelinating diseases in humans and animals show, myelin as isolation sheath of nerve fibres has essential functions. It is a membrane of very specific composition the components of ...