Browsing Human- und Zahnmedizin by Referee "Thelen, Paul PD Dr."
Now showing items 1-12 of 12
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HDAC inhibitor valproic acid increases CRABP2 expression and in combination with retinoic acid synergistically inhibits proliferation in glioblastoma cells
(2016-12-12)Background: Although integrated treatments were implemented, glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors. The cellular retinoic acid–binding protein 2 (CRABP2) plays a crucial role, ... -
Metabolisches Syndrom: Die Effekte von 20-Hydroxyecdyson und 17-beta-Östradiol auf das Fettgewebe und die subkutane Körpertemperatur der ovariektomierten Ratte
(2014-12-08)Effects of visceral body fat were shown in ovariectomized rats after 4 weeks application of ecdysone. Reduction of mean body temperature has been proved after 1 week of ecdysone- application in ovariectomized rats. -
Charakterisierung östrogener Effekte von Genistein im Modell der langzeitovarektomierten Maus
(2014-10-14)In recent years, phytoestrogens increasingly gained attention in the field of medical science, as they represent a potential alternative to classical hormone replacement therapy for climacteric affliction, which is is ... -
Die Effekte von endokrinen Disruptoren auf den Herzmuskel orchidektomierter Ratten
(2014-04-28)OBJECTIVE The effects of endocrine disruptors (ED) on the reproductive organs are extensively studied as a variety of endocrine disrupting substances have estrogenic and anti-androgenic effects. Since both, estrogen and ... -
Molekularpathologie seltener Sarkomentitäten des Urogenitaltraktes
(2013-11-07)Soft tissue sarcomas of the genito-urinary tract are really rare and aggressive tumors with rapid tumor progression and early metastatic disease. Despite the histological similarity of these small-, round- and blue cell ... -
Wirkungen endokriner Disruptoren auf Prostata und Samenblase der Sprague-Dawley-Ratte
(2012-02-28)Endocrine disruptors (ED) are substances that, due to their chemical structure, can interfere with endocrine system of animals, including humans and caused adverse biological effects. They ... -
Die Wirkung von Valproat auf die Konochenmetastasenzellen (VCaP) des Prostatakarzinoms
(2011-09-16)In Germany prostate cancer is the most common malignant tumour in male humans. In this study the therapeutic effects of valproic acid (VPA), which is known to be a histone deacetylase (HDAC) ... -
Der Effekt von 20-Hydroxyecdyson auf die Tibia orchidektomierter und ovarektomierter Ratten, gemessen mittels peripherer quantitativer Computertomographie
(2011-05-31)20-Hydroxyecdysone (=Ecd) is a steroidal substance of herbal origin with osteoprotective effects on mammal bone, which by now has only been proved by a few studies. The present study ... -
Funktionelle Analyse des Prostate-derived-Ets-Factors (PDEF) in der Prostatakarzinomzelllinie LNCaP
(2011-05-09)PDEF a co-regulator of the androgen receptor shows a marked tumour-associated expression. The role of PDEF in cancer cell invasiveness is currently under investigation. To study the function ... -
Einfluss von Estradiol, Genistein, Equol und Resveratrol auf verschiedene östrogensensitive Organe und Parameter der ovariektomierten Maus
(2011-01-26)Introduction: The effects of estrogen replacement therapy regarding cardioprotective effects remain controversial and attract number of studies that focus on both genomic and non-genomic ... -
HGF als anti-fibrotisches Agens: Effekte der Überexpression in renalen Fibroblasten und Tubulusepithelzellen
(2010-11-03)Chronic renal disease is affected by tubular interstitial fibrosis and lead to end stage renal failure. Mediated by chemokines inflammatory cells are recruited, proinflammatory mediators ... -
Kurzzeiteffekte von Estradiol, Raloxifen, Phytohormonen und Parathormon auf die metaphysäre Frakturheilung des manifest osteoporotischen Knochens der Ratte
(2010-06-15)Most people suffering from osteoporosis are undiagnosed: the first osteoporotic fracture strikes an untreated organism. Therefore, implant fixation often fails or bone healing is disturbed. ...