Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Groß, Uwe Prof. Dr."
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Identifizierung und Charakterisierung der Dihydroorotat Dehydrogenase als Zielstruktur von 1-Hydroxyquinolonen in Toxoplasma gondii
(2014-01-06)1-Hydroxyquinolones were recently described as effective inhibitors of Toxoplasma gondii replication. These compounds (e.g. HDQ and compound B) were previously shown to inhibit the alternative NADH dehydrogenase (NADH2-I) ... -
IFN-γ-vermittelte Infektabwehr von <i>Toxoplasma gondii</i> in murinen Skelettmuskelzellen <i>in vitro</i>
(2011-05-17)Toxoplasma gondii is a widespread intracellular parasite which is able to infect any nucleated cell of warm-blooded animals and humans leading to a lifelong persistence of T. gondii ... -
Impact of Toxoplasma gondii on STAT1 activity and epigenetic regulation during IFN-γ signaling of its host cell
(2018-08-21)Toxoplasma gondii is an obligate intracellular parasite which infects up to 30% of humans world-wide. To control T. gondii, the host mounts a strong IFN-γ-driven immune response via the signal transducer and activator of ... -
Investigating the role of lipocalin-2 as a diagnostic indicator for nonalcoholic steatohepatitis in a fructose-induced rat fatty liver model: First experimental studies
(2013-12-17)The liver is the vital organ for fat and carbohydrate metabolism as well as detoxification and excretion of metabolites. Any functional impairment will thus affect the whole organism and is absolutely undesirable. Nonalcoholic ... -
Kompartementalisierung des Kohlenhydrat-Stoffwechsels in Toxoplasma gondii
(2006-12-11)Toxoplasma gondii is an obligate intracellular parasite and which is able to infect and replicate within nearly any eukaryotic, nucleated cell. In the intermediate host the parasite ... -
Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
(2009-02-02)Toxoplasma gondii is an obligate intracellular apicomplexan parasite. Due to its broad spectrum of hosts and its lifelong persistence in the host it is one of the most successful parasites. ... -
Modulation of Gene Expression of Iron Regulatory Proteins, Hemeoxygenase-1 and Lactoferrin, in Mice Liver and Muscle by Different Cytokines, In Two Models of Acute Phase Reaction.
(2010-05-07)Iron is indispensable to living organisms. Iron homeostasis is orchestrated both at the cellular and the systemic level, and liver plays a central role in the regulation of iron ... -
Molecular and Functional Characterization of Programmed Cell Death (PCD) in Toxoplasma gondii
(2013-05-06)Toxoplasma gondii is a protozoan parasite which leads to widespread infections in humans and animals worldwide. Infection is typically asymptomatic in immunocompetent hosts, but may lead to severe symptoms in immunocompromized ... -
Oxidative stress pathways in the pathogenesis of renal fibrosis
(2016-05-23)In the pathogenesis of renal fibrosis, oxidative stress (OS) enhances the production of reactive oxygen species (ROS) leading to sustained cell growth, inflammation, excessive tissue remodelling and accumulation, which ... -
Die parasitophore Vakuole des Mikrosporidiums Encephalitozoon cuniculi: Biogenese und Metabolitaustausch
(2008-11-12)Microsporidia possess a unique invasion mechanism, which is based on the explosive extrusion of a hollow tube, the so called polar tube, from the microsporidian spore. The common infection ... -
Proteomic investigation of the molecular targets of mycophenolic acid in human cells
(2012-02-14)Mycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key regulator of purine biosynthesis. MPA is frequently used as an immunosuppressant drug to ... -
Regulation of HPr phosphorylation in Mycoplasma pneumoniae
(2006-11-08)The genome of the mollicute Mycoplasma pneumoniae contains only 688 genes. Among the very few regulatory proteins retained is the HPr kinase/phosphorylase (HPrK/P) of the phosphoenolpyruvate:sugar ... -
Regulation of Toxoplasma gondii bradyzoite differentiation in terminally differentiated skeletal muscle cells
(2017-11-28)Toxoplasma gondii is an intracellular protozoan parasite that infects warm-blooded animals including an estimated thirty percent of humans world-wide. In immunocompetent host, primary infection is usually asymptomatic but ... -
Rheumatoide Arthritis: Proteomische Analyse von Serum und synovialen Fibroblasten zur Detektion von Biomarkern
(2009-06-23)The rheumatoid arthritis (RA) is a chronic systematic inflammatory disorder that affects primarily the peripheral joints and will lead to a progressive destruction of the articular cartilage ... -
Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
(2012-02-28)Lipocalin-2 (LCN-2) is a pleiotropic 25-kDa secretory protein, currently used as a biomarker for renal injury and inflammation. Its serum level is increased under different pathological ... -
Transcription in Mycoplasma pneumoniae
(2010-10-12)The human pathogen Mycoplasma pneumoniae has maintained only a small repertoire of genes putatively involved in transcription regulation. This reflects its adaption to a nutrient rich and ... -
Untersuchungen zu den selbst-replizierenden Eigenschaften des pathogenen Prion-Proteins beim Menschen
(2016-02-11)Prion diseases are transmissible, fatal neurodegenerative diseases of humans and animals. They are linked to the conversion of the cellular prion protein (PrPC) into its pathogenic form (PrPSc). Due to this conversion prion ... -
Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii
(2008-11-17)Toxoplasma gondii is a world wide spread and obligate intracellular protozoan parasite, which induces mostly asymptomatic, lifelong persisting infections in humans. Furthermore, it is an ... -
Variability of biofilm formation in Candida glabrata and Candida parapsilosis and its consequences on the infection process
(2019-08-30)The prevalence of Candida species has increased in the last two decades, becoming the third to fourth most common cause of infections in hospitals. In general, Candida spp. are opportunistic pathogens found as commensals ... -
Zellspezifische Funktionen des Typ 1 Interferonrezeptors bei der experimentellen autoimmunen Enzephalomyelitis
(2007-11-22)Multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease of the central nervous system (CNS), the etiology of which remains unclear. It is generally held that ...