Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Einsle, Oliver Prof. Dr."
Now showing items 1-20 of 22
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Structural characterization of the two copper proteins nitrous oxide reductase from Pseudomonas stutzeri and laccase Lcc5 from Coprinopsis cinerea
(2011-08-24)Although, the reduction of nitrous oxide (N2O) is highly exergonic, a high activation barrier hinders a spontaneous reaction. With regard to inertness, N2O is second only to molecular ... -
Biochemische Charakterisierung von PpoA aus Aspergillus nidulans
(2010-02-17)In the present work Psi-factor- producing oxygenases from Aspergillus nidulans, so called Ppo-enzymes have been studied and characterized. These enzymes are known to possess regulatory ... -
Studien zur Pathogenese humaner Leukoenzephalopathien
(2009-09-17)Leukoencephalopathies present a group of inborn, mostly neurodegenerative diseases. The aim of this work was to investigate two of these leukoencephalopathies: the GJA12-associated ... -
Die Bedeutung der Proteine 4.1G und 4.1N für den Aufbau und die Funktion glutamaterger Synapsen
(2009-09-14)In the present study, the role of proteins 4.1G and 4.1N for the synaptic localisation of AMPA receptors and neurotransmission at glutamatergic synapses in the mouse brain has been examined. ... -
Ein neuer Syntheseweg für wertvolle Fettsäuren in Saccharomyces cerevisiae und Arabidopsis thaliana
(2009-04-03)The production of very long chain fatty acids (VLCPUFAs) with relevance for human nutrition in transgenic oilseeds represents a major challenge for plant biotechnology. Up to now, VLCPUFA ... -
Purification and crystallization of spliceosomal snRNPs
(2009-02-26)In eukaryotes, the non-coding sequences (introns) of precursor messenger RNA are excised by a large ribonucleoprotein complex, the spliceosome. The core components of the spliceosome are ... -
Functional and structural investigation of spliceosomal snRNPs
(2009-01-20)The expression of most eukaryotic protein-encoding genes involves precursor messenger RNA (pre-mRNA) processing steps including pre-mRNA splicing. Pre-mRNA splicing is catalyzed by a ... -
Mobilisierung von Speicherlipiden in <i>Cucumis sativus</i>- und <i>Arabodopsis thaliana</i>-Keimlingen
(2008-12-12)Germination of oilseeds is characterized by mobilisation of TAGs that are stored in lipid bodies and serve as carbon source. Beside the classical degradation pathway of these storage ... -
Structural and biochemical characterization of diheme <i>c</i>-type cytochromes
(2008-12-04)Cytochromes are an abundant family of proteins incorporating heme as a prosthetic group and are involved in processes of electron conduction or redox reactions. Heme consists of an aromatic ... -
Structure Determination of Viscotoxin A1, Tendamistat and Tri Peptidyl peptidase-I
(2008-10-22)The current work reports the methods used to elucidate crystal structures of the target proteins using experimental phasing as well as their structure analysis.Viscotoxins belong to the ... -
Kristallstrukturanalyse des spleißosomalen DEAD-Box Proteins hPrp28
(2008-06-25)DEAD-box proteins belong to the helicase superfamily. They use the energy of ATP hydrolysis to dissociate RNA-RNA or RNA-protein interactions and therefore to catalyze rearrangements in ... -
Thermodynamische und strukturelle Charakterisierung Importinβ-abhängiger Kernimportprozesse
(2008-03-18)Active nuclear transport of cytoplasmic substrates into the nucleus is mediated by transport receptors also termed importins. Among them the nuclear import receptor importinβ (Impβ) is presumably the most versatile one: ... -
Blue light-dependent development of the filamentous fungus Aspergillus nidulans
(2007-11-22)Numerous studies have revealed that fungal development and the production of secondary metabolites are linked although the molecular mechanisms are yet unknown. Light seems to be one of the ... -
Chararcterisation of fungal protein kinases involved in the regulation of the cell cycle of Saccharomyces cerevisiae and of sexual development in Aspergillus nidulans
(2007-11-22)In this work, fungal model organisms, the single cell budding yeast Saccharomyces cerevisiae and the filamentous fungus Aspergillus nidulans were used to characterize different factors ... -
Structural Analysis of the 50S Ribosomal Stalk
(2007-06-27)Protein biosynthesis represents a dynamic process that takes place on the ribosome and is driven by translation factors. Some of these factors are GTP binding proteins. They possess a limited ... -
Kristallisation von GGA-Proteinen und röntgenkristallographische Untersuchungen am Cα-Formylglycin Generierenden Enzym
(2007-03-05)GGA proteins are a family of monomeric clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Crystal structures of isolated GGA protein VHS, GAT and GAE ... -
„Ex vivo” Replikation des pathogenen Prion Proteins
(2007-01-29)The prion protein (PrP) is an ubiquitous protein. Prion stands for proteinaceous infectious particle and is according to the 'protein-only hypothesis' the infective agens of the transmissible ... -
Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP
(2007-01-29)Subject of this thesis is the splicesosmal U5-particle. The functional relationship of the proteins is investigated by means of limited proteolysis and spectroscopy. Due to the splicesosome's ... -
Crystal structure of a human U5 snRNP specific binary complex and crystal structure of a histone deacetylase-like bacterial amidohydrolase
(2005-12-09)The crystal structure of the complex comprising the GYF-domain of U5-52K and the U5-15K protein has been determined at 2.35 Å resolution. The protein U5-52K (Lin1p) is a component of yeast ... -
Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen
(2005-10-25)Cystine knot microproteins are peptidic biomolecules with approximately 28-40 amino acids in length. They are able to fold into extremely stable threedimensional structures characterized ...