Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hoyer-Fender, Sigrid PD Dr."
Now showing items 1-20 of 22
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Analysis of coiled coil domain containing 33 protein (CCDC33) and determination of infertility causes in mutant mouse line with the deletion of six germ cell-specific genes
(2013-02-27)Since most cases of male infertility remain idiopathic, analysis of the mechanism in which genes are involved in spermatogenesis control might help to better understand the reasons. This thesis consists of 2 parts concerning ... -
Expression and Functional Analysis of Vsig1 Gene
(2009-05-27)The aims of this study were to determine expression pattern and subcellular localization of VSIG1, a novel member of the immunoglobulin superfamily, and to analyse the function of the Vsig1 ... -
Kristallstrukturanalyse des spleißosomalen DEAD-Box Proteins hPrp28
(2008-06-25)DEAD-box proteins belong to the helicase superfamily. They use the energy of ATP hydrolysis to dissociate RNA-RNA or RNA-protein interactions and therefore to catalyze rearrangements in ... -
Herstellung und Charakterisierung monoklonaler Antikörper gegen die Anaphylatoxin-Rezeptoren
(2008-01-29)Anaphylatoxins are potent pro-inflammatory mediators that induce their biological effects through high affinity binding to specific cellular receptors. Due to controversial evidence in the ... -
Funktionelle Analyse des murinen Foxq1 Gens und die Charakterisierung magenspezifischer Gene
(2007-11-09)This work clearly demonstrates an involvement of Foxq1 in gastric acid secretion. Our results let us suggest, that Foxq1 takes part in the organisation of tubulovesicle transport or the ... -
In vivo- und in vitro-Funktionsanalysen von Bax Inhibitor-1 bei humanen Karzinomzellen
(2007-05-29)Apoptosis is a form of programmed cell death, which is regulated by numerous gene products. Many of these genes are mutated or deregulated in human carcinoma. Bax inhibitor-1 (BI-1) gene ... -
Creation and establishment of transgenic mouse models for for Mecp2 gene, causing Rett syndrome
(2007-05-08)The MeCP2 protein is a transcriptional repressor binding to methylated cytosines and modifying the chromatin structure. Mecp2 gene was eventually found to be the cause of 95% of Rett Syndrome cases. In spite of its ubiquitous ... -
Expression and functional analyses of murine Pelota (Pelo) gene
(2007-04-25)In the present study, we have studied the expression pattern of Pelo at the protein level with the help of polyclonal anti-Pelo antibody and generation of conditional inactivation, which ... -
Funktionelle Analyse des murinen Sall4-Gens
(2007-01-02)Mutations in human SALL4 gene cause Okihiro syndrome, an autosomal dominant disorder characterised by radial ray abnormalities and Duane anomaly and some other anal, renal, cardiac, ear, ... -
Untersuchung des transkriptionellen Mechanismus der Igf2- Überexpression in Patched-assoziierten Tumoren
(2006-12-06)For a better understanding of the formation and progression of Rhabdomyosarcoma (RMS) in heterocygous Ptch mutants, the present study was devoted to the transcriptional mechanisms of ... -
Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen
(2006-04-04)Noonan Syndrome (NS) [OMIM 163950] is an autosomal dominant disorder characterized by short stature, facial dismorphism, webbed neck, heart defects (most commonly pulmonic stenosis and ... -
Functional Analysis of the Dynein Light Chain Genes, <i>Dnali1</i> and <i>Tcte3</i>
(2006-02-01)In the present study, the function of two murine genes, Dnali1 and Tcte3 were investigated. Murine Dnali1 gene is a homologue of Chlamydomonas p28 and belongs to the family of inner arm ... -
Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells
(2005-11-25)In the present study expression and functional analysis of two testis specific genes, namely Tex18 and Stra8 was performed.RT-PCR, made for the expression analysis of Tex18 gene showed it ... -
Mechanismen der Entwicklung des zerebralen Kortex
(2005-01-19)The current concept of the cerebral cortex patterning involves certain genes with a region specific expression in the cortical primordium, such as paracrine factors and transcription factors. ... -
Molecular and Functional Analysis of two Gene Trap Mouse Lines
(2004-05-10)For better understanding of the mechanisms regulating mammalian embryonic development, the isolation and characterization of new genes involved in this mechanism is important. A useful tool ... -
Expression and functional analysis of the germ cell specific genes ADAM 27 and Testase 2
(2004-02-12)In the present study two members of the ADAM family of proteins, murine ADAM 27 and Testase 2, were characterized. Both genes are expressed specifically in the testicular germ cells and therefore are postulated to be ... -
Zur Expression und Funktion von Prm3: ein ungewöhnliches Protamin
(2003-10-28)In this work the Protamin3 (Prm3) gene as well as the resulting protein were characterized. Because this gene, along with the two other protamins (Prm1 and Prm2), is located in the same ... -
Funtional Analysis of the Murine Genes, MOCS1 and Sox15
(2003-08-06)In this work, function of the murine genes, MOCS1 and Sox15 were investigated. Human molybdenum cofactor deficiency is a rare and devastating autosomal-recessive disease for which no therapy ... -
Isolation and functional analysis of differentially expressed genes in human prostate cancer
(2003-02-27)Prostate cancer is the most frequently diagnosed solid tumor in men, and the second leading cause of cancer death in males from western countries. One of the key issues in prostate cancer ... -
Elucidation of Theg Gene Role in Spermatogenesis and Characterisation of a Novel Spontaneous Mutation Named “nax” in Mouse
(2003-02-11)In the present study, a differentially expressed gene, named Theg, expressed specifically in spermatids, is characterised. Its expression is up regulated by some unknown factor/s from Sertoli ...