Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hoyer-Fender, Sigrid Prof. Dr."
Now showing items 1-20 of 46
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Mammalian spermiogenesis and the formation of the sperm head to tail coupling apparatus
(2021-08-24)The head-tail coupling apparatus (HTCA), also known as connecting piece, provides the physical linkage between the sperm head and its tail. The HTCA morphogenesis initiates during spermiogenesis and is assembled at the ... -
Role of BRD4 and its target Ptp1b in Endothelial cells and in cardiovascular disease models
(2019-03-15)Vascular and lymphatic system is lined by Endothelial cells (ECs) monolayer or endothelium. Healthy endothelium maintains vessel functions by releasing different substances including Nitric Oxide (NO). Cardiovascular risk ... -
Embryonic and foetal germ cell development in the marmoset monkey: comparative in situ and cell culture studies
(2018-11-12)Primordial germ cells (PGCs) are the precursors of sperm and egg cells. They arise early in mammalian embryonic development and have to translocate from their extraembryonic tissue of specification over a significant ... -
Modeling anthracycline-induced cardiotoxicity with patient-specific iPSCs
(2018-04-17)The anthracycline doxorubicin (DOX), one of the most effective chemotherapeutic drugs for the treatment of various cancers, is limited in its clinical applications due to cumulative dose-dependent cardiotoxicity. The ... -
Molecular role of Pelota (PELO) in differentiation of embryonic and germ stem cells
(2015-11-05)Pelota (Pelo) is an evolutionary conserved gene, which has been characterized in diverse species. In mouse, Pelo deficiency results in embryonic lethality at early post-implantation stage. The in vitro culture of Pelo-null ... -
CEP72 represents a putative Oncogene that negatively regulates the mitotic Function of Brca1 and induces Chromosomal Instability
(2015-10-26)Proper progression through mitosis ensures the maintenance of whole chromosomal stability in a eukaryotic cell. Hence, failures during this tightly regulated process can lead to the perpetual mis-segregation of whole ... -
From stem cells to male germ cells: Experimental approaches for the in vitro generation of mouse and human spermatogonial stem cells
(2015-06-24)Currently different in vitro experimental approaches make use of the unique potential of pluripotent cells in order to produce functional sperm aiming at the establishment of new treatment opportunities for male infertility. ... -
Identifizierung neuer Coregulatoren von SOX9 und RUNX2 in chondrogenen Progenitorzellen in der Osteoarthrose
(2015-06-23)Osteoarthritis is a degenerative disease of the joints. It is characterized by a successive destruction of the articular cartilage and surrounding structures. Osteoarthritis is the most common musculoskeletal joint disease ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
In situ and in vitro analysis of germ and stem cell marker-positive cells in the postnatal ovary of the common marmoset monkey (Callithrix jacchus)
(2014-07-25)Oogonia are the proliferating diploid germ cells within the female gonad giving rise to oocytes. Oocytes are the meiotic female germ cell stages. In humans, almost all oogonia enter meiosis between weeks 9 and 22 of prenatal ... -
Human and mouse meniscus progenitor cells and their role in meniscus tissue regeneration
(2014-05-19)Osteoarthritis (OA) is a degenerative disease of hyaline cartilage. The cartilage is an avascular tissue, once damaged it is difficult to repair. Articular cartilage is responsible for the smooth, frictionless, and painless ... -
Analyse zur Rolle von pflanzlichen Wirkstoffen und Histondeacetylase-Inhibitoren auf Wachstumsfaktoren und deren Signalwege in Prostatakarzinomzellen
(2013-12-19)Prostate cancer (PCa) is the most frequently new diagnosed cancer entity and the third leading cause of cancer-related deaths of men in Germany. The options for therapy of PCa are restricted and most of them have strong ... -
Der Rotmilan (Milvus milvus) im Unteren Eichsfeld.
(2013-11-19)In the present study were examined population density, habitat use and composition, young bird rearing, food and predation on Red Kite (Milvus milvus). Essential questions were how stable is the stock in the area and what ... -
miRNA functions in pluripotency and spermatogenesis
(2013-10-23)For quite a long time, non-coding RNAs (ncRNAs) were discriminated and considered as an evolutionary error. In light of this opinion, discovery of small ncRNAs, in particular microRNA (miRNA), which can regulate the gene ... -
Die Rolle der IGF-Achse in Kombination mit anderen Wachstumsfaktor-Signalwegen bei der Resistenz oder dem Ansprechen von kolorektalen Karzinomen auf eine Radiochemotherapie
(2013-10-11)In the Western world cancer represents one of the major health problems. Colorectal cancer (CRC) is the third most common tumor incidence. In advanced disease, in most cases a combined radiochemotherapy (RCT) is performed, ... -
Studying synaptopathies using Mecp2 transgenic mouse models
(2013-09-05)The MECP2 gene is located in the Xq28, which encodes for methyl-CpG binding protein 2 (MeCP2). Mutations in MECP2 gene is the primary cause of postnatal neurodevelopmental disorder, Rett syndrome (RTT) (loss-of-function). ... -
Charakterisierung der Sumoylierung von p35, dem Aktivator der Zyklin-abhängigen Kinase 5 (Cdk5), und der daraus resultierenden funktionellen Konsequenz
(2013-05-28)For the central nervous system development and neuron-specific functions, including neurite outgrowth as well as synaptic function and plasticity, cyclin-dependent kinase (Cdk) 5 has a central role. Cdk5 activity requires ... -
Untersuchung bispezifischer Intradiabodies gegen die Integrine avb3, avb5 und a5b1 auf ihre anti-angiogenen Eigenschaften
(2013-02-21)Angiogenesis, the growth of new blood vessels from preexisting vasculature, is a fundamental process in development, wound repair and reproduction. This process is influenced by growth factors, such as vascular endothelial ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
Calreticulin in kidney function and disease: chronic low level of calreticulin impairs Ca2+ homeostasis leading to mitochondrial dysfunction and chronic renal injury
(2012-11-28)Chronic kidney disease (CKD) is becoming a major public health problem worldwide. The persistent progression of CKD is postulated to result from a self-perpetuating vicious cycle of events activated after initial injury. ...