Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Kramer, Wilfried PD Dr."
Now showing items 1-20 of 41
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
Structure and function of microbial communities involved in biomineralization
(2022-01-27)Different aspects of carbonate precipitation are considered in this study. The first part examines carbonates in a model system that helps to explain the initial steps in the formation of so-called concretions, which are ... -
Morphological and molecular adaptation of Aspergillus niger to simulated spaceflight and Mars-like conditions
(2021-10-18)The International Space Station (ISS) is an indoor-closed environment in Low Earth Orbit (LEO). Outside of the ISS, radiation is the most challenging factor outside. In turn, inside the ISS, spaceflight microgravity is the ... -
Localization and Function of RNases in Bacillus subtilis
(2017-03-29)The ability to adapt to changing environmental conditions is essential for every organism to survive. In bacteria, this adaptation relies on the control of the mRNA synthesis, stability, and turnover, which allows the ... -
Untersuchung der submitochondrialen Verteilung von Oxa1 und Mba1 in Saccharomyces cerevisiae
(2016-04-21)The mitochondria of eucaryotic cells are involved in several cellular processes and fulfill a multitude of fundamental tasks, such as the production of energy via the process of oxidative phosphorylation. They exhibit a ... -
Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime
(2016-01-28)Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients. However, its use is sporadically linked to the leak flux diarrhea and other ... -
Effect of radiation on hepatic fat metabolism in rat and mouse: A role of radiation-induced TNF-α in the regulation of FAT/CD36
(2015-08-13)Radiotherapy is an important method to treat tumors. The positive effects of irradiation on tumoral tissue are thought to be due to the damage of the DNA of tumor cells and the damage of tumor vessels. Radiation as single ... -
Analyse und Charakterisierung regulatorischer Vorgänge in Bacillus licheniformis
(2015-05-08)Analysis of RNA-Seq data in a genome context sensitive approach to identify known and novel RNA-regulatory elements and events applied by Bacillus licheniformis DSM13 to adapt its physiology to a productive fermentation. ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Entwicklung von diagnostischen Methoden zum Nachweis von europäischen humanpathogenen Arboviren
(2014-10-17)A majority 50-70% of aseptic meningo-encephalitis cases is caused by unknown aetiological agents.
In the course of this work a cytometric bead array (CBA) for simultaneous detection of antibodies against ...
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Feinkartierung humoraler Immunantworten von Makaken nach Immunisierung und/oder viraler Infektion mittels Peptid - Microarray
(2014-10-02)The aim of this study was to map humoral immune responses in rhesus macaques (RM) which had either been immunized and/or infected with different viruses. This was achieved by screening serum samples using peptide microarrays. ... -
Establishment of human lymphoma cell lines with different thiopurine S-methyltransferase (TPMT) activities and differential proteome analysis after thiopurine exposure.
(2013-04-09)Thiopurines are purine analogues used as immunosuppressive and antileukemic agents. Thiopurine activation requires extensive metabolism that involves many enzymatic reactions and TPMT is one of the crucial enzymes in the ... -
Untersuchung bispezifischer Intradiabodies gegen die Integrine avb3, avb5 und a5b1 auf ihre anti-angiogenen Eigenschaften
(2013-02-21)Angiogenesis, the growth of new blood vessels from preexisting vasculature, is a fundamental process in development, wound repair and reproduction. This process is influenced by growth factors, such as vascular endothelial ... -
An mRNA degradation complex in Bacillus subtilis
(2011-12-14)In every organism the degradation of mRNAs is a fundamental process. This step not only recycles nucleotides but also adjusts gene expression due to the availability of the mRNA templates. The main players in this process ... -
Function of MCPH1 in Neurogenesis
(2011-06-22)Primary Microcephaly (MCPH), an autosomal recessive disorder, is characterized by a reduction of the brain size in particular the cerebral cortex size. MCPH can be caused by mutations in ... -
Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212
(2011-05-16)Mth212, an exonuclease III homolog from the archaeon Methanothermobacter thermoautotrophicus, compensates the lack of a DNA uracil glycosylase (UDG) in this organism by catalyzing direct ... -
Identification and characterization of virulence associated factors of C. jejuni
(2010-11-25)Campylobacter jejuni, an important food-borne human bacterial pathogen in industrialized countries and in the developing world, the leading cause of bacterial diarrhoea. The infection may ... -
Transkriptomanalyse der <i>Arabidopsis</i>-Wurzel nach Infektion mit dem pilzlichen Pathogen <i>Verticillium longisporum</i> und Identifizierung von transkriptionellen Regulatoren der Pathogenantwort
(2010-04-08)Verticillium longisporum is a soil-borne fungal pathogen causing vascular disease within a narrow host range of brassica species. It is a mayor pest in oilseed rape cultivation causing ...