Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Simons, Mikael Prof. Dr."
Now showing items 1-10 of 10
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Identification and characterization of proteomic regulations in the cerebellum region of brain in MM1 and VV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD)
(2017-05-17)Sporadic Creutzfeldt–Jakob disease (sCJD) is a fatal, transmissible spongiform encephalopathy (TSE) characterized by broad range of clinical and pathological manifestations. Pathological features of sCJD are largely dependent ... -
Functional properties of microglia in mouse models of Alzheimer’s disease
(2017-02-13)Microglia, resident macrophages of the CNS, execute various functions: they participate in oligodendrogenesis, neurogenesis, learning and behavior, phagocytose harmful material as well as tissue debris and mount crucial ... -
Characterization of exosomes as a diagnostic marker in neurodegenerative diseases
(2016-10-28)α-Synuclein pathology has been hypothesized to propagate in synucleinopathies by intercellular transfer of pathogenic seeds in a prion-like fashion. Extracellular release of α-Synuclein via small extracellular vesicles has ... -
Unraveling psychiatric sub-phenotypes: The price of the reduction of myelin basic protein
(2016-07-29)Myelin, the proteolipidic layer that wraps around the axon, is one of the evolutionary advantages for animals with complex behaviour and reasoning. Myelin ensures axonal support and synchronised electrical communication ... -
Extracellular vesicle release of α-Synuclein is mediated by SUMOylation
(2015-11-13)We hypothesized that cells release and transfer α-Syn associated with EVs, followed by highly efficient internalization and induction of α-Syn aggregation in previously healthy neurons. EVs of 40-100 nm diameter can either ... -
Genome-wide RNAi screening reveals glial phosphoethanolamine ceramide is critical for axonal ensheathment
(2012-11-07)Glia play a major role in many processes during the development of the nervous system both in vertebrates and in invertebrates. One of the crucial functions of glia is the insulation of axons to provide them with trophic ... -
The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
(2011-05-04)The extent of the permanent clinical disability in multiple sclerosis patients emerges from axonal damage and loss. In this study, we show a major role of the low affinity neurotrophin ... -
Prion protein-induced proteome alterations in sporadic Creutzfeldt-Jakob disease and in SH-SY5Y cell culture model
(2011-01-11)Cellular prion protein (PrPC) is a glycosylated membrane glycoprotein mainly expressed in the central nervous system. Some still undefined molecular events can lead to the conversion of ... -
The Diversity of TLR4-triggered Responses in Mouse Microglia
(2010-10-08)Microglia are the major immunocompetent effector cells of the CNS. Steadily monitoring their neighborhood they are always ready to transform to activated states upon encounters with ... -
Role of miRNAs in Oligodendrocyte Development
(2010-09-10)MicroRNAs (miRNAs) are important for the regulation of various processes in cell biology. However, the function of miRNAs in the central nervous system and especially in glial cells is still ...