Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Wienands, Jürgen Prof. Dr."
Now showing items 1-15 of 15
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The enzymatic product of SH2 domain-containing inositol 5-phosphatases supports the fitness of BCR-dependent Burkitt lymphoma cells by promoting the energy metabolism
(2023-11-23)Burkitt lymphoma (BL) is an aggressively growing neoplasm owing to an over expression of the MYC oncogene and exploitation of the tonic B cell receptor (BCR) signaling for its survival. While it is known that the survival ... -
Biophysical characterization and computational modeling of phase separation of immune adapter proteins
(2022-07-07)The processes of B cell activation and development are stimulated by antigen binding to the B cell receptor. Pre-signaling clusters are present in unstimulated, resting B cells and assemble by tripartite phase separation ... -
Global Analysis of Protein Phosphorylation Regulation upon Stimulation of Exocytosis in the Nerve Terminal
(2017-06-14)In chemical synapses, neurons communicate with each other via two mechanisms known as fast and slow synaptic transmission. Fast synaptic transmission happens within milliseconds and is triggered by the arrival of an action ... -
Characterization of chondrogenic progenitor cells using mass spectrometry and multidimensional separation approaches
(2015-07-03)Modern day mass spectrometry (MS) has evolved into a powerful analytical technique, central to the field of proteomics. Currently, the identification and quantification of proteins from different biological samples can be ... -
Immunogenicity of pluripotent stem cells and their differentiation products
(2013-06-12)Embryonic stem cells (ESCs) hold great promises for regenerative medicine since they are able to differentiate into any cell type of an adult body. However, transplantation of these cells is associated with at least two ... -
Myokardinfarktregeneration unter Verwendung kardiovaskulärer Vorläuferzellen aus murinen und humanen pluripotenten Stammzellen
(2013-02-19)Stem cells hold a great promise in regenerative therapies for cardiovascular diseases. Heart regeneration with stem cells requires a delicate balance between the loss of donor cell pluripotency (so that teratoma formation ... -
The kinase MK2 in DNA replication upon genotoxic stress and chemotherapy
(2013-01-11)DNA damage constitutes a constant threat to genomic integrity. Cells evolved programs controlled by a complex signaling network to cope with these lesions in order to avoid tumorigenesis. These cellular processes and ... -
The NF-κB signaling pathway in melanoma cells and implications for its therapeutic modulation
(2012-12-10)One of the major challenges in cancer therapy is to overcome drug resistance. Melanoma cells are an illustrative example for this notion, as metastasized melanoma is almost universally resistant against chemotherapy. The ... -
Comparison of expression pattern and localization of iron transport proteins in rat liver, brain and spleen during acute phase response:invivo and invitro studies
(2012-02-09)Acute phase is clinically characterized by homeostatic alterations such as somnolence, adinamia, fever, muscular weakness and leucocytosis. Dramatic changes in iron metabolism are observed ... -
Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
(2011-02-24)This PhD thesis reports the characterisation of the genetic diversity of killer cell immunoglobulin like receptors (KIR) as well as interactions between KIR and MHC class I molecules in the ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
UPSTREAM PATHWAYS REGULATING ERYTHROPOIETIN GENE EXPRESSION IN THE LIVER DURING ACUTE PHASE RESPONSE: A CENTRAL ROLE FOR IL-6.
(2010-08-18)The acute phase response is the systemic reaction of an organism to insults like infection, trauma, or burning and it represents the first line of defense of the body to tissue-damaging ... -
Effect of Radiation on Leukocytes Migration and Gene expression of Rat Liver Chemokines: In-vivo and In-vitro Studies
(2010-02-01)Liver damage is a serious clinical complication of gamma-irradiation. CXC- and CC-chemokines, known to attract inflammatory cells, play a role in transmigration process during inflammation. Chemokines are generated locally ... -
Electron microscopic localization of tagged proteins in the yeast S. cerevisiae spliceosomal U4/U6.U5 trisnRNP
(2008-10-30)Pre-mRNA splicing is catalyzed by a macromolecular machine called spliceosome . The spliceosome is assembled in a stepwise manner from the small nuclear ribonucleoprotein particles (snRNPs), ... -
Diversity and Habitat Selection of Papilionidae in a Protected Forest Reserve in Assam, Northeast India
(2008-02-19)The habitat association by forest type and distribution pattern, seasonal abundance, correlation between mean abundance and geographic range and the feeding guild and indicator properties of swallowtail butterflies ...