Dokumente GZMB - Göttinger Zentrum für molekulare Biowissenschaften nach Gutachter "Kramer, Wilfried PD Dr."
Anzeige 1-4 von 4
-
Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ... -
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur
(2010-02-09)The aim of this study was to identify individual host markers for hematologic side effects and treatment efficacy of dacarbazine or temozolomide in melanoma treatment. Such markers could facilitate the decision for or ... -
Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
(2008-06-05)Patched (Ptch), a component of the Hedgehog (Hh)/Ptch signalling cascade, is frequently mutated in basal cell carcinoma (BCC), medulloblastoma (MB) and rhabdomyosarcoma (RMS). Ptchneo67/+ mice, in which exons 6 and 7 are ... -
Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ...