Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Jahn, Reinhard Prof. Dr."
Now showing items 1-20 of 46
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Synthesis of Modified Biomolecules to Investigate Neuronal Processes
(2021-04-30)Action potentials are an essential process for signal transmission in excitable cells. At chemical synapses, the action potential triggers the release of neurotransmitters from synaptic vesicles to transmit the signal to ... -
Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes
(2021-02-19)Membrane proteins play an important role in cellular function as receptors, transporters, anchors, and catalysts. Despite constituting 20-30% of the human proteome only 3 % of all characterized proteins are membrane proteins ... -
Elucidation of protein interactions in complex samples by protein-protein cross-linking of synaptosomes
(2019-08-23)Synapses are essential structures for inter-cellular communication in the central nervous system between neuronal cells. They form highly-specialized compartments that convert electrical to chemical signals, i.e. ... -
Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
Hybrids of SNARE Transmembrane Domains and Artificial Recognition Motifs as Membrane Fusion Inducing Model Peptides
(2018-03-13)Protein mediated fusion of membranes is a crucial biological process. For instance, SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are involved in neuronal exocytosis. However, ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Synthesis and Investigation of Nucleobase Functionalized β-Peptide as SNAREs Model System for Membranefusion
(2015-07-22)In this work, the novel simplified SNARE-mimicking systems consisting of TMD/linker segments of the natural membrane-bound SNARE proteins (syntaxin-1A and synaptobrevin 2) with a nucleobase functionalized β-peptide (β-PNA) ... -
Transport Mechanisms of the Vesicular Glutamate Transporter 1
(2013-05-08)In neuronal signal transmission, vesicular neurotransmitter transporters play a key role in quantal size modification. They are filling synaptic vesicles (SVs) with neurotransmitter, fuelled by an electrochemical gradient ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ... -
Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa
(2012-02-22)Establishment and maintenance of cellular polarity are important and fundamental processes in eukaryotes, which have to be coordinated with cell division, differentiation, and cell growth. ... -
Biochemistry and physiological role of otoferlin
(2011-11-24)In humans deafness is caused by environmental but also by genetic factors. Mutations in the gene encoding otoferlin are one genetic cause of deafness, leading to DFNB9 an autosomal recessive ... -
Role of the different domains of PSD-95 in basal synaptic transmission
(2011-11-09)Learning and memory has been postulated to rely on changes in synaptic transmission strength. At excitatory synapses in the hippocampus CA1 region, synaptic strength is mainly regulated by ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Mechanisms of Multivesicular Body Biogenesis and Exosome Release
(2010-06-10)Exosomes are small vesicles with a diameter of approximately 50-100 nm that are secreted by a number of different cells and function in a multitude of intercellular signaling processes. ... -
On the chloride dependence of vesicular glutamate transport
(2010-06-10)Neurons release neurotransmitters in discrete amounts, the quanta. The transmitters are stored in small membrane-bound organelles, the synaptic vesicles, in the vicinity of the plasma ... -
Neue Einblicke in die SNARE-vermittelte Fusion: Detektion einzelner Proteoliposomen mit einem konfokalen Mikroskop
(2010-01-15)Neuronal exocytosis is of special interest amongst the multitude of membrane fusion processes taking place in different eukaryotic cells. Understanding the mechanism of fusion between the ... -
Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
(2010-01-06)Increased endogenous neurogenesis can be observed after cerebral ischemia in mice, but fails to significantly contribute to neural regeneration or integration. Therefore, the local application ... -
The timing of the final assembly of the SNARE complex in exocytosis
(2010-01-05)Transfer of information between individual neurons via exocytosis is mediated by fusion of secretory vesicles with the plasma membrane and requires assembly of the SNARE proteins Syntaxin-1, SNAP-25 and Synaptobrevin 2 ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ...