Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse

Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse

Structural and functional characterisation of filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice

Sebastian Rahrig

Doctoral thesis

Date of Examination: 2020-03-05

Date of issue: 2020-02-14

Advisor: Schön, Michael P. Prof. Dr.

Referee: Walter, Lutz Prof. Dr.

Referee: Meyer, Thomas Prof. Dr.

Persistent Address: http://hdl.handle.net/21.11130/00-1735-0000-0005-1320-1

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Abstract

English

Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute a risk factor for atopic dermatitis and eczema-related asthma. Furthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis. Thus, mice deficient for Flg and Hrnr provide a novel model to study skin barrier impairment and the susceptibility for cutaneous inflammation.

Keywords: allergic contact dermatitis; filaggrin; homerin; skin barrier

Schlagwörter: allergische Kontaktdermatitis; Filaggrin; Hornerin; Hautbarriere