Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz

Effects of cardiovascular risk factors as well as various pre-existing diseases on the course of Alzheimer's dementia

von Marilis Fricke
Dissertation
Datum der mündl. Prüfung:2021-06-29
Erschienen:2021-06-22
Betreuer:Prof. Dr. Inga Zerr
Gutachter:Prof. Dr. Inga Zerr
Gutachter:PD Dr. Steffen Unkel
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-8687

 

 

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Zusammenfassung

Englisch

Alzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. Within this dissertation 90 patients with Alzheimer’s were examined in a study of the University Medical Centre Göttingen. Based on a minimum of two follow up examinations using the MMSE (Mini Mental State Examination), patients were classified into two groups: Alzheimer’s dementia and rapidly progressive Alzheimer’s disease. A multitude of risk factors including cardiovascular risk factors, cancer, surgical intervention and other risk factors were examined retrospectively with regard to their contribution to the classification into one of the groups, and their connection to a faster cognitive decline of the patients. We found evidence, that patients suffering from Alzheimer’s and diabetes mellitus or coronary heart disease showed a significantly slower cognitive decline in this cohort. Possible reasons for this observation could be crossing neurochemical pathways in both Alzheimer’s disease and diabetes mellitus. The effect of antidiabetic or antihypertensive medication could play an important role, too. Prospective studies with more detailed information concerning the risk factors are required to identify reasons leading to this context. Other risk factors showed no impact on cognitive development within the two groups.
Keywords: Alzheimer's disease; risk factors; rapidly progressive Alzheimer's disease; Diabetes mellitus
Schlagwörter: Alzheimer-Demenz; Risikofaktoren; rapid progressive Alzheimer-Demenz; Diabetes mellitus
 
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