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A Functional Characterisation of Drosophila Chordotonal Organs

dc.contributor.advisorGöpfert, Martin Prof. Dr.de
dc.contributor.authorWiek, Robert Jagode
dc.date.accessioned2013-06-27T08:35:50Zde
dc.date.available2013-06-27T08:35:50Zde
dc.date.issued2013-06-27de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0001-B986-9de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3910
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc570de
dc.titleA Functional Characterisation of Drosophila Chordotonal Organsde
dc.typedoctoralThesisde
dc.contributor.refereeGöpfert, Martin Prof. Dr.de
dc.date.examination2013-06-21de
dc.description.abstractengFunctional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium imaging. As sinusoidal stimulation at relative small stimulus amplitudes elicited changes in intracellular ionic calcium (Ca2+) concentration in the FCO, the effect of substrate vibration on Drosophila walking behaviour was proposed. But lately developed fly tracking software for high-throughput ethomics (Branson et al., 2009) showed that substrate vibrations have no specific effect on Drosophila walking behaviour. Instead present evidence suggests that Drosophila compensates for substrate vibration by detection via the FCO and therefore is able to control its body posture. A modification of transcuticular in vivo Calcium imaging was used to locate the neuronal activity region of Inactive, a protein involved in Drosophila hearing and a mechanotransduction channel candidate. Here I show that Inactive mutants still respond to sound like stimulation with ciliary calcium currents.de
dc.contributor.coRefereeFiala, André Prof. Dr.de
dc.contributor.thirdRefereeBüschges, Ansgar Prof.Dr.de
dc.subject.engFCOde
dc.subject.engJOde
dc.subject.engTRPde
dc.subject.engTRPVde
dc.subject.enginactivede
dc.subject.engsubstrate vibrationsde
dc.subject.engmechanotransductionde
dc.subject.engauditory transduction of soundde
dc.subject.engCalcium imagingde
dc.subject.engCameleon 2.1de
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0001-B986-9-9de
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullBiologie (PPN619462639)de
dc.identifier.ppn750586451de


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