Browsing Molekulare Medizin by Advisor "Flügel, Alexander Prof. Dr."
Now showing items 1-6 of 6
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Mechanisms of T-cell mediated inflammatory neurodegeneration
(2025-04-04)Multiple sclerosis (MS) is a T-cell mediated, chronic, demyelinating disease of the central nervous system (CNS). Neurodegeneration and axonal loss are associated with increased disability and disease progression. ... -
T cell-mediated ocular autoimmunity
(2025-03-07)Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system (CNS), leading to inflammatory lesions in the brain and spinal cord. The autoimmune process can affect both the gray and ... -
Characterization of myelin-specific autoantibodies in an EAE mouse model
(2023-10-02)Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease ... -
The Role of Glycolysis in shaping the Autoimmune Potential of Myelin-Reactive T Cells in the Course of Experimental Autoimmune Encephalomyelitis
(2019-10-11)Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), where myelin-reactive T cells play a key role in the inflammatory events responsible for the formation of demyelinated lesions. Auto-reactive ... -
Live Analysis of the Role of B cells in Experimental Autoimmune Encephalomyelitis
(2016-01-08)During the last years it has become increasingly clear that autoantigen-specific B cells play a pathogenic role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, their ... -
Migratory Cues For Encephalitogenic Effector T Cells Within The CNS During The Different Phases Of EAE
(2013-06-17)In multiple sclerosis (MS), encephalitogenic T cells are considered to breach distinct cerebral barriers in order to gain access to their target tissue, the CNS. However, it remains poorly understood exactly how auto-reactive ...