Browsing Molekulare Medizin by Advisor "Zeisberg, Elisabeth Prof. Dr."
Now showing items 1-4 of 4
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Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
TET3 IMPACTS CARDIAC FIBROSIS PARTIALLY VIA REGULATION OF DNA DAMAGE RESPONSE
(2020-02-12)Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferative stimuli but ... -
Crosstalk of macrophages and endothelial cells in endothelial-to-mesenchymal transition and cardiac fibrosis
(2017-07-27)Cardiac fibrosis (CF) is an integral component of virtually all forms of chronic cardiac disease. CF manifests as an accumulation of excessive extracellular matrix (ECM) components throughout the myocardium. Aberrant ... -
Induced pluripotent stem cells from patients with hypoplastic left heart syndrome (HLHS) as a model to study functional contribution of endothelial-mesenchymal transition (EndMT) in HLHS
(2016-11-30)Hypoplastic left heart syndrome (HLHS) is one of the most lethal congenital heart diseases (CHD) and its pathological mechanism remains unclear. Endocardial fibroelastosis (EFE) is a hallmark of HLHS which impairs myocardial ...