Browsing Molekulare Medizin by Advisor "Zelarayán, Laura C. PD Dr."
Now showing items 1-4 of 4
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In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
Molecular mechanisms of TBX5-related conduction disorders
(2021-08-24)Background Cardiovascular disease is a common cause of death. About 60 % of cardiovascular mortality is attributable to sudden cardiac death, mostly caused by arrhythmia. The origin of arrhythmia can be an underlying ... -
Wnt-TCF7L2-dependent transcriptional and chromatin dynamics in cardiac regeneration, homeostasis and disease
(2018-11-12)Wnt/β-catenin-dependent signaling pathway is indispensible for cardiac development, becoming quiescent in the normal adult heart, and re-activated in both regenerative responses post-injury and in cardiac hypertrophy and ... -
The Role of the Insulin-like Growth Factor Binding Protein 5 (IGFBP5) in Cardiogenesis and Cardiac Remodelling
(2018-10-15)The importance of elucidating mechanisms of cardiac regulatory networks during cardiogenesis is underscored by the re-activation of fetal gene expression in the diseased adult heart. To further understand this phenomenon, ...