Browsing Molekulare Medizin by Referee "Jarry, Hubertus Prof. Dr."
Now showing items 1-13 of 13
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Molecular mechanisms of TBX5-related conduction disorders
(2021-08-24)Background Cardiovascular disease is a common cause of death. About 60 % of cardiovascular mortality is attributable to sudden cardiac death, mostly caused by arrhythmia. The origin of arrhythmia can be an underlying ... -
Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
Exosomes as Potential Transport Vehicles of Tetrahydrobiopterin, 6-Pyrovyoltetrahydrobiopterin-Synthase and Tripeptidyl-Peptidase I
(2018-12-14)Extracellular vesicles (EV) for the therapeutic application are of growing scientific interest. But even though the number of clinical trials on EVs almost doubled from 29 to 52 within 2017, the number of trials with ... -
The role of estrogen receptors in prostate cancer development and their role in new treatment opportunities
(2017-08-29)The androgen receptor (AR) signaling pathway is one of the key pathways deregulated in prostate cancer (PCa). Different attempts to inhibit AR signaling failed to be curative. Therefore, the targeting of other pathways ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
RhoGTPases and their relevance for the afterload-dependent myocardial fibrosis
(2016-12-06)The guanine exchange factor p63RhoGEF was identified as a specific activator of the RhoGTPase RhoA and its transcript was found to be abundant in brain and heart tissue. Amongst cardiac cells, the highest expression of ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
New approaches to improve Extracorporeal Photopheresis for the treatment of Graft-versus-Host Disease
(2016-05-25)Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity ... -
Amyloid beta 4-42 in Alzheimer’s disease: Target, Therapy, Mechanism
(2016-04-14)Targeting Aβ has recently been the main objective in Alzheimer’s disease therapeutic approaches. Passive immunization trials have encountered undesirable side effects but the therapy remains a promising option. Aβ4-x has ... -
Cardiac and fibroblastic properties after HIF-1α stabilization
(2015-06-01)The cellular oxygen sensing prolyl-4-hydroxylase domain proteins (PHDs) are essential regulators of the α-subunit of hypoxia-inducible transcription factors (HIFs) which are known to induce a variety of genes affecting ... -
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
(2014-07-17)Regulation of human salt and fluid homeostasis is of basic biological importance. Kidney functions allow surviving under a wide variety of conditions with high or low salt diets and with high or low intake of fluids, even ...