Browsing Molekulare Medizin by Referee "Simons, Mikael Prof. Dr."
Now showing items 1-11 of 11
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The Role of Glycolysis in shaping the Autoimmune Potential of Myelin-Reactive T Cells in the Course of Experimental Autoimmune Encephalomyelitis
(2019-10-11)Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), where myelin-reactive T cells play a key role in the inflammatory events responsible for the formation of demyelinated lesions. Auto-reactive ... -
Regional-dependent, comprehensive characterization of miRNA signatures in sporadic Creutzfeldt-Jakob Disease and early Alzheimer’s Disease-type neuropathology
(2019-10-09)The pathogenic mechanisms and the origins of neurodegenerative diseases remain unclear on molecular level. Increasing evidences postulate alterations in miRNA signatures as critical factor in pathogenesis, progression ... -
The role of astrocytes in murine models of toxic demyelination
(2016-08-30)In demyelinating diseases such as multiple sclerosis (MS) activated astrocytes, characterised by up-regulation of the intermediate filament glial fibrillary acidic protein (GFAP), were shown to have beneficial as well as ... -
Live Analysis of the Role of B cells in Experimental Autoimmune Encephalomyelitis
(2016-01-08)During the last years it has become increasingly clear that autoantigen-specific B cells play a pathogenic role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, their ... -
Functional proteome analysis of age associated PrPC knockout mice liver along with regulatory response of cytoskeleton associated tau protein and fatty liver disease.
(2015-12-03)PrPC is a membrane associated cellular glycoprotein. Its mis-folded form, PrPSc causes a set of neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs). PrPC is abundantly expressed in the brain ... -
Characterization of blood-brain barrier disruption in a focal model of neuromyelitis optica
(2015-11-20)Neuromyelitis optica (NMO) is a demyelinating autoimmune disease of the central nervous system (CNS), with serum anti-aquaporin4 (AQP4) antibodies (Ab) detected in the majority of patients. Binding of NMO-Ab to AQP4 results ... -
The Kv10.1 voltage gated potassium ion channel modulates the cell adhesion and cell migration hallmarks of cancer
(2015-06-23)A characteristic of the Kv10.1 voltage-gated potassium ion channel is its overexpression in a number of cancerous tissues and cancer cell lines, even though it should normally be restricted to the adult brain and myoblasts. ... -
The role of astrocytic RFX4_v3 in demyelination
(2015-05-11)RFX4_v3 is the brain-specific splice variant of the transcription factor RFX4 (Blackshear et al., 2003; Matsushita et al., 2005). It was shown to play an important role during early brain development and in the genesis of ... -
Studying the Interactions of Cytotoxic T Cells with Neurons in vivo
(2013-12-13)The central nervous system (CNS) is considered as largely isolated from the immune system – a status referred to as “immune privilege”. But CNS-tissue is constantly surveyed by immune cells and can under certain circumstances, ... -
Dissecting and Modeling Oncogene Dependent Molecular Mechanisms in Lymphoma Genesis and Progression
(2013-11-18)Aggressive Non-Hodgkin lymphomas (aNHL) are a heterogeneous group of lymphomas. The constellation of oncogenic pathway activities can vary in patients with the same malignant disease. The pathological mechanisms behind the ... -
Migratory Cues For Encephalitogenic Effector T Cells Within The CNS During The Different Phases Of EAE
(2013-06-17)In multiple sclerosis (MS), encephalitogenic T cells are considered to breach distinct cerebral barriers in order to gain access to their target tissue, the CNS. However, it remains poorly understood exactly how auto-reactive ...