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dc.contributor.advisor Knöll, Ralph Prof. Dr. de
dc.contributor.author Kirova, Aleksandra de
dc.date.accessioned 2013-01-14T15:26:16Z de
dc.date.available 2013-01-30T23:50:52Z de
dc.date.issued 2012-06-20 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-000D-EFD2-7 de
dc.format.mimetype application/pdf de
dc.language.iso eng de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ de
dc.title Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin de
dc.type doctoralThesis de
dc.title.translated Funktionale und Mutationale Analyse von der Kinase Domäne des Gigantischen Protein Titin de
dc.contributor.referee Lutz, Susanne Prof. Dr. de
dc.date.examination 2012-06-26 de
dc.subject.dnb 610 Medizin, Gesundheit de
dc.subject.gok MED 411 de
dc.description.abstracteng The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its anchorage at the Z-disc and M-line, the protein is proposed to participate in the mechanosensation and -transduction, to provide mechanical stability to the sarcomere as well as to possibly serve as a “molecular ruler, de
dc.contributor.coReferee Schu, Peter Prof. Dr. de
dc.subject.topic Medicine de
dc.subject.ger titin de
dc.subject.ger dilatative Kardiomyopathie de
dc.subject.ger mechanotransduktion de
dc.subject.ger Hefe-Dihybrid de
dc.subject.eng titin de
dc.subject.eng dilated cardiomyopathy de
dc.subject.eng mechanotransduction de
dc.subject.eng yeast two hybrid de
dc.subject.bk 44.85 de
dc.identifier.urn urn:nbn:de:gbv:7-webdoc-3573-2 de
dc.identifier.purl webdoc-3573 de
dc.affiliation.institute Medizinische Fakultät de
dc.identifier.ppn 728919354 de

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