Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin

Kirova, Aleksandra

dc.contributor.advisor	Knöll, Ralph Prof. Dr.	de
dc.contributor.author	Kirova, Aleksandra	de
dc.date.accessioned	2013-01-14T15:26:16Z	de
dc.date.available	2013-01-30T23:50:52Z	de
dc.date.issued	2012-06-20	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-EFD2-7	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-1555
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin	de
dc.type	doctoralThesis	de
dc.title.translated	Funktionale und Mutationale Analyse von der Kinase Domäne des Gigantischen Protein Titin	de
dc.contributor.referee	Lutz, Susanne Prof. Dr.	de
dc.date.examination	2012-06-26	de
dc.subject.dnb	610 Medizin, Gesundheit	de
dc.subject.gok	MED 411	de
dc.description.abstracteng	The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its anchorage at the Z-disc and M-line, the protein is proposed to participate in the mechanosensation and -transduction, to provide mechanical stability to the sarcomere as well as to possibly serve as a “molecular ruler,	de
dc.contributor.coReferee	Schu, Peter Prof. Dr.	de
dc.subject.topic	Medicine	de
dc.subject.ger	titin	de
dc.subject.ger	dilatative Kardiomyopathie	de
dc.subject.ger	mechanotransduktion	de
dc.subject.ger	Hefe-Dihybrid	de
dc.subject.eng	titin	de
dc.subject.eng	dilated cardiomyopathy	de
dc.subject.eng	mechanotransduction	de
dc.subject.eng	yeast two hybrid	de
dc.subject.bk	44.85	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3573-2	de
dc.identifier.purl	webdoc-3573	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.identifier.ppn	728919354	de

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