Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Enderlein, Jörg Prof. Dr."
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On the Use of Temporal Information for the Reconstruction of Magnetic Resonance Image Series
(2020-10-28)Standard clinical magnetic resonance imaging uses data sampled at the Nyquist rate which limits it to frame rates of 1-4 frames per second. Over the past decade different methods for the reconstruction of images from ... -
Optical bionanosensors for neurotransmitter detection
(2018-10-17)Information transfer in the human brain is enabled by neurotransmitters - messenger molecules that diffuse between cells. Static concentration measurements are useful to identify molecules involved in neurotransmission, ... -
Optimal navigation in active matter
(2023-07-11)Motile active matter systems are composed of a collection of agents, each of which extracts energy from the surrounding environment in order to convert it into self-driven motion. At the microscopic scale, however, directed ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Oscillatory instabilities of intracellular fiber networks
(2015-12-02)D. discoideum shares many common features of actin dynamics and essential responses with eukaryotic cells and cancer cells. Therefore, most properties of the oscillations are well studied in the simpler biological model ... -
Perturbation of Pattern Formation in Dictyostelium Discoideum via Flow and Spatial Heterogeneities
(2020-04-07)In this thesis, we investigate the signalling process of the social amoeba Dictyostelium discoideum (D. discoideum) as a model reaction-diffusion-advection system. Colonies of these cells are an excitable medium that ... -
Probing Molecular Stoichiometry by Photon Antibunching and Nanofluidics Assisted Imaging in Solution
(2017-07-05)A mechanistic understanding of biological function requires a quantitative determination of macromolecular subunit architecture and interaction. Optical microscopy and spectroscopy provide a noninvasive method to characterize ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Ribosome dynamics during spontaneous frameshifting
(2022-10-18)During protein synthesis, the ribosome moves along the mRNA in steps of three nucleotides at a time to maintain the translational reading frame. However, on some mRNA sequences that are denoted as slippery, ribosomes may ... -
Scale-dependent Response of Fluid Turbulence under Variation of the Large-scale Forcing
(2016-02-03)In this work, an experiment to measure the temporal evolution of energy transfer at different scales in a turbulent flow that was subject to a perturbation of the energy injection is described. Two types of experiments ... -
Self-Organization in Catalytically Active Mixtures
(2023-08-14)Living systems are intrinsically out of equilibrium, which makes their physical description challenging. This has led to the emergence, over the past thirty years, of a new field of physics, active matter, which studies ... -
Self-organization of microtubules for biomimetic structures
(2021-07-05)Biological polymers that build up the eukaryotic cytoskeleton exhibit a rich dynamical behaviour that aid a multitude of cellular processes. Microtubules, together with their associated motor proteins in the cell are ... -
Single Molecule Fluorescence Spectroscopy and Imaging: Advanced Methods and Applications in Life Sciences
(2021-06-03)The visualization of biological structures down to the molecular length scale has been recently made possible by the development of super-resolution fluorescence microscopy. These techniques now routinely resolve biological ... -
Stochastic Optical Fluctuation Imaging - Labels and Applications
(2015-05-26)Superresolution fluorescence imaging is an important tool for studying subcellular structures and processes. A technique with great potential is stochastic optical fluctuation imaging (SOFI), a fluorescence imaging modality ... -
The Advantages Of Paramagnetic NMR
(2013-11-28)There are three distinct effects in nuclear magnetic resonance spectroscopy (NMR) that differ between paramagnetic and diamagnetic molecules in isotropic solution. These are residual dipolar coupling (RDC), pseudocontact ... -
The Principles of Self-Organization of Memories in Neural Networks for Generating and Performing Cognitive Strategies
(2018-12-12)Higher-order animals exhibit the remarkable ability to dynamically adapt to a changing environment. On the neuronal level, they have to form mental representations of specific stimuli, so-called memories. Furthermore, ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
The Viscoelastic Response of Liquid Crystalline Fibers Formed By Bent-core Molecules
(2019-11-20)A free-standing fluid fiber must suppress the radial fluctuations described by the Rayleigh- Plateau (R-P) instability. The stability of such structures are typically restricted to polymers or naturally-occurring spider ...