Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Issue Date
Now showing items 41-60 of 1172
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Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ... -
Conservation and divergence of the retinal homeobox genetic neural lineage between Drosophila melanogaster and Tribolium castaneum
(2024-06-25)Brains are the central organ integrating sensory information and orchestrating behaviour. Their function and development are of great scientific interest, but their enormous complexity makes them difficult to study. The ... -
Computational biology and bioinformatic methods in neuropsychiatric research: From autoimmunity to cognition and erythropoietin
(2024-06-24)Research in neuropsychiatry has greatly developed in terms of complexity, both in the questions addressed and the datasets used. Advances in computational biology and bioinformatic methods have been essential to this ... -
Dynamics and Machine Learning Inference using Memory in Stochastic Biochemical Reaction Networks
(2024-06-24)In this thesis we study the dynamics of non-equilibrium stochastic chemical reaction networks with a special focus on biochemical networks. In the regime of large intrinsic noise where the numbers of participating molecules ... -
Auditory descending neurons in the prothoracic network of the bush cricket Ancistrura nigrovittata
(2024-06-20)Ancistrura nigrovittata is a duetting phaneropterine bush cricket species. Males sing with a fixed temporal and spectral pattern, the characteristics of which are important for recognition; females reply to the song with ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Characterisation of primate primordial germ cells in vitro
(2024-06-17)Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
Feature Selectivity in Synthetic Neuronal Networks
(2024-06-06)A fundamental property of neurons in the primary visual cortex is their preference for orientation of edges. In primates and carnivores orientation selective neurons are organized into functional domains that are arranged ... -
Structural and functional connectivity in patients with major depressive disorder undergoing accelerated intermittent theta burst stimulation
(2024-06-05)Major depressive disorder (MDD) is one of the most prevalent mental health conditions, primarily characterized by depressed mood and loss of interest or pleasure. Cognitive impairments, including psychomotor agitation ... -
Reconstruction of Cardiac Wave Dynamics from Mechanical Deformation
(2024-05-24)Cardiac arrhythmias, such as atrial and ventricular fibrillation, are caused by abnormal electrical activity within the heart muscle, leading to irregular contractions and potentially life-threatening situations. Current ... -
A Quantitative Mass Spectrometric Analysis of Signalling Proteins in Human Sperm Cells
(2024-05-17)Fertilization of an oocyte by a sperm cell is a complex multi-stage process. First, a sperm cell must locate and reach the oocyte; second, it must undergo capacitation, the acrosome reaction, and hyperactivation to penetrate ... -
Regulation of the Hrd1 Ubiquitin ligase during protein degradation at the endoplasmic reticulum
(2024-05-16)Misfolded or redundant proteins of the endoplasmic reticulum are degraded via ER associated degradation: They are recognized, undergo a retrotranslocation into the cytosol, become ubiquitinated, are extracted from the ... -
New redox-switches in proteins
(2024-04-26)Regulation of cellular pathways in response to the redox state of a cell is an important regulatory process. A well-established paradigm of redox-sensing is disulfide formation between two cysteine residues and cysteine ... -
Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Structural and functional analyses of the HECT E3 ligase HACE1
(2024-04-19)Many crucial cellular processes rely on post-translational modifications. In particular, the covalent attachment of ubiquitin molecules, termed ubiquitylation, onto substrates, typically via lysine residues, is most commonly ... -
An investigation of cell turnover in the planarian epidermis
(2024-04-16)Cell turnover is an important biological process for maintaining tissue homeostasis. During cell turnover, newly generated cells replace unwanted cells to balance the number of cells and ensure the functionality of a tissue. ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ...