Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Braus, Gerhard Prof. Dr."
Now showing items 1-20 of 23
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The role of Hsp42 in proteostasis-metabolism interplay and cellular longevity
(2025-01-23)Aging is a natural phenomenon characterized by a progressive decline despite complex pathways of maintenance and repair. Over time, cells experience profound changes in cell morphology as well as alterations in gene ... -
Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis
(2024-07-23)The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ... -
Identification of factors involved in cell wall homeostasis and tolerance towards quaternary ammonium compounds in Listeria monocytogenes by genomic adaptation
(2023-06-20)Listeria monocytogenes is one of the most successful food-borne pathogens worldwide. Despite available treatment with cell wall targeting antibiotics an infection with concomitant development of listeriosis results in death ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
The Verticillium effector XFORCE1 targets a core component of plant mRNA turnover and induces cell identity switches
(2023-02-17)Previous research into Verticillium spp. infection on the model plant Arabidopsis thaliana revealed the existence of three distinct disease classes. Each of these could be characterised by the induction of contrasting ... -
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
(2021-10-19)Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ... -
Impact of Nitrogen Nutrition and Ectomycorrhizal Interaction on Populus x canescens Xylem Sap Composition and Defense
(2020-10-15)Nitrogen (N) is an essential macro-nutrient for plant growth and development. Inorganic N is taken up by plant roots as ammonium (NH4+) or nitrate (NO3-). Roots of tree species are colonized by mycorrhizal fungi, which ... -
Defense remodelling by ectomycorrhizal fungi in non-hosts
(2020-08-04)Root colonizing beneficial microorganisms promote growth of host plants and protect them against biotic threats. These microbes are considered as sustainable replacements for the hazardous chemical treatments in agriculture. ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
Atg21 restricts Atg8 lipidation to a novel vacuole-phagophore contact site
(2019-07-01)Macroautophagy is a degradative membrane trafficking pathway that removes and recycles cellular components to maintain cellular homeostasis. Targets for degradation are a variety of cytosolic components including protein ... -
Proteomics of Aspergillus nidulans sexually differentiated cells
(2018-10-01)The homothallic mold Aspergillus nidulans produces as overwintering structures closed sexual fruiting bodies named cleistothecia, which contain ascospores as products of meiosis. Formation of fruiting bodies is linked to ... -
Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Novel Applications of Super-Resolution Microscopy in Molecular Biology and Medical Diagnostics
(2016-03-31)Despite recent advances in microscopy techniques, the underlying labeling assays remained mostly unchanged. However, super-resolution techniques require other staining conditions than conventional light microscopy, like ... -
Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A
(2016-01-22)Macroautophagy is a conserved catabolic pathway for the removal and recycling of cytosolic components, damaged or surplus organelles, protein aggregates or intracellular pathogens to maintain cellular homeostasis. It is ... -
The STRIPAK complex and its role in fruiting-body development of the filamentous fungus Sordaria macrospora
(2015-09-23)The mammalian Striatin-interacting phosphatase and kinase (STRIPAK) complex consist of many proteins, among them Striatin as scaffold, the putative kinase activator monopolar spindle-one-binder 3 (MOB3), serine/threonine ... -
Functional and structural analysis of carbonic anhydrases from the filamentous ascomycete Sordaria macrospora
(2014-05-14)Carbonic anhydrases (CAs) are metalloenzymes catalyzing the rapid and reversible hydration of carbon dioxide to bicarbonate (hydrogen carbonate) and protons. CAs have been identified in archaea, bacteria and eukaryotes and ... -
Role of methyltransferases in fungal development and secondary metabolite production
(2014-02-17)Fungal development and secondary metabolism are controlled by environmental signals through regulatory proteins. VeA protein is the founding member of the velvet superfamily of fungal regulators. It is involved in light ... -
Mechanistic insights into alpha-Synuclein neuronal toxicity: misfolding, serine phosphorylation and interactions with Rab GTPases
(2013-11-18)Alpha-Synuclein(aS), a protein abundant in presynaptic neurons, has been found as the major component of Lewy bodies, the neuronal inclusion identified as the hallmark of Parkinson’s disease (PD). aS adopts intrinsically ... -
Sumoylation of Nuclear Transport Receptors and the small GTPase Ran
(2013-08-08)Sumoylation has been linked to nucleocytoplasmic transport since the discovery of SUMO as a modifier of vertebrate RanGAP1, which is targeted to the nuclear pore complex (NPC) after sumoylation. The link between sumoylation ...