Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Ehrenreich, Hannelore Prof. Dr. Dr."
Now showing items 1-20 of 27
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BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Environmental and genetic correlates of neuropsychiatric diseases and the role of erythropoietin/hypoxia in the brain as potential treatment targets
(2021-06-15)Neuropsychiatric disorders are relatively frequent and present a considerable burden to affected individuals and society. Disease etiology is often complex and patients exhibit large heterogeneity regarding disease causing ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ... -
Investigation of myelin maintenance and turnover by inducible MBP knock-out in adult mice
(2019-11-11)The turnover and maintenance of myelin in the adult CNS Myelin is a multilayered membrane structure generated by oligodendrocytes in the CNS that insulates and supports axons. While most of the oligodendrocyte population ... -
Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
MicroRNA-212/132 Family is Involved in the Regulation of Long-Term Spatial Memory and Synaptic Remodeling
(2014-10-30)MicroRNAs are noncoding transcripts with crucial functions in probably every organ system. The roles of miRNAs in neuronal processes and cognitive functions are recently being appreciated. The discovery of neuronal activity ... -
Modeling anti-NMDAR encephalitis
(2022-07-22)The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of ... -
Neuronal pathology in targeted cortical experimental autoimmune encephalomyelitis and multiple sclerosis
(2013-07-09)In the recent years it has become increasingly obvious that multiple sclerosis (MS) is not only a white matter (WM) disease of the central nervous system (CNS) but also involves frequently and extensively the grey matter ... -
Novel approaches to measure physiological and behavioral responses to stress
(2020-02-21)Stress is the perception of threats to one's physical or psychological integrity, leading to certain autonomous, affective, and behavioral responses. Albeit its important role in adapting to new contexts and thus increasing ... -
Pathological Alterations Induced by intraneuronal in Alzheimer’s Disease
(2010-01-18)Alzheimer’s disease (AD) is pathologically characterized by the deposition of amyloid beta (Aβ) and neurofibrillary tangles (NFT) consisting of hyperphosphorylated tau protein. Since familial mutations in proteins ... -
Peripheral nervous system control for neuroprostheses
(2017-09-21)Amputee patients who have lost a hand or arm are severely impaired in their daily life, as they lose the ability to grasp and interact with their environment. While the use of electromyographically controlled prosthetic ... -
Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
(2011-05-02)Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate gene ... -
Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
(2018-04-23)Anxiety disorder is a debilitating condition that affects up to 10% of the adult population in the world. Mapping of brain activity in patients and in mouse models has shown that anxiety- related behavior is associated ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ... -
Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ...