Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Enderlein, Jörg Prof. Dr."
Now showing items 1-20 of 60
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Advancements in Nanobody Applications: From Live Synaptic Imaging to Multiplexed Fluorescence Microscopy and Nanoscale Topography Mapping
(2024-12-09)Fluorescence microscopy facilitates biological research by enabling straightforward visualization of fluorescently labeled proteins in live and fixed samples. Despite significant progress in microscopy techniques, including ... -
Reconstruction of Cardiac Wave Dynamics from Mechanical Deformation
(2024-05-24)Cardiac arrhythmias, such as atrial and ventricular fibrillation, are caused by abnormal electrical activity within the heart muscle, leading to irregular contractions and potentially life-threatening situations. Current ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ... -
Collective Behaviour of Filamentous Cyanobacteria
(2024-01-11)Cyanobacteria are the oldest phototrophic organisms on the planet. Having been responsible for the “Great Oxidation Event” millions of years ago, it has enabled the development and sustenance of multi-cellular life forms, ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Self-Organization in Catalytically Active Mixtures
(2023-08-14)Living systems are intrinsically out of equilibrium, which makes their physical description challenging. This has led to the emergence, over the past thirty years, of a new field of physics, active matter, which studies ... -
Optimal navigation in active matter
(2023-07-11)Motile active matter systems are composed of a collection of agents, each of which extracts energy from the surrounding environment in order to convert it into self-driven motion. At the microscopic scale, however, directed ... -
Cotranslational folding of HemK C-terminal domain
(2023-03-17)The correct folding of proteins is essential for the survival of the cell. Despite the importance of the question, it remains largely unclear how proteins, in particular large multidomain proteins with mixed α-helical and ... -
A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation
(2022-12-14)Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ... -
Dynamics and self-organization of membrane-bound minimal actin and actomyosin cortices based on ezrin-PtdIns[4,5]P2 linkage
(2022-11-22)The cellular cortex is a thin actin layer attached to the cytoplasmatic plasma membrane leaflet of mammalian cells. Through a complex interaction with hundreds of actin binding proteins (ABPs), controlling e.g. the cortex ... -
Ribosome dynamics during spontaneous frameshifting
(2022-10-18)During protein synthesis, the ribosome moves along the mRNA in steps of three nucleotides at a time to maintain the translational reading frame. However, on some mRNA sequences that are denoted as slippery, ribosomes may ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Self-organization of microtubules for biomimetic structures
(2021-07-05)Biological polymers that build up the eukaryotic cytoskeleton exhibit a rich dynamical behaviour that aid a multitude of cellular processes. Microtubules, together with their associated motor proteins in the cell are ... -
Single Molecule Fluorescence Spectroscopy and Imaging: Advanced Methods and Applications in Life Sciences
(2021-06-03)The visualization of biological structures down to the molecular length scale has been recently made possible by the development of super-resolution fluorescence microscopy. These techniques now routinely resolve biological ... -
Fluorescence Lifetime Single Molecule Localisation Microscopy
(2021-03-26)In conventional fluorescence microscopy, species are distinguished by colour. While these images provide an abundance of information about the sample, they are, in many aspects limited by artefacts and resolution, and some ... -
Multi-Directional Phase-Contrast Flow MRI in Real Time
(2021-01-28)This work describes the development of a phase-contrast MRI technique that achieves multi-directional velocity quantification in real time, i.e. at high spatio-temporal resolution and without any physiological gating or ... -
Advances in enhanced multi-plane 3D imaging and image scanning microscopy
(2021-01-07)High-speed 3D optical microscopy is an indispensable requirement in studying rapid processes like signaling in neuronal networks, flagellar motion, or complex motion of living and highly dynamic subcellular components. ... -
On the Use of Temporal Information for the Reconstruction of Magnetic Resonance Image Series
(2020-10-28)Standard clinical magnetic resonance imaging uses data sampled at the Nyquist rate which limits it to frame rates of 1-4 frames per second. Over the past decade different methods for the reconstruction of images from ... -
Constitutive Modeling for Tissue Engineered Heart Repair
(2020-10-27)Computer-aided therapy design is an intricate endeavor intertwining all scales from molecules to cells and tissues to organs. Changing one such component in a living system can have far-reaching effects, diffcult to ...