Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Kessel, Michael Prof. Dr."
Now showing items 1-12 of 12
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The role of mammalian TRC40 in membrane-protein targeting and chaperoning
(2019-05-24)Tail-anchored (TA) proteins are distinguished from other membrane proteins due to their particular topology. The best-characterized pathway for the targeting of TA-proteins is the GET pathway in yeast or the TRC pathway ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
XDazl function in RNA metabolism in Xenopus laevis
(2015-11-25)Germ cell specification in Xenopus laevis depends on the inheritance of maternal determinants from the oocyte in form of mRNAs and proteins. At the onset of zygotic transcription, maternal mRNAs are subjected to miR-mediated ... -
MicroRNA-212/132 Family is Involved in the Regulation of Long-Term Spatial Memory and Synaptic Remodeling
(2014-10-30)MicroRNAs are noncoding transcripts with crucial functions in probably every organ system. The roles of miRNAs in neuronal processes and cognitive functions are recently being appreciated. The discovery of neuronal activity ... -
Studying Protein Organization in Cellular Membranes by High-Resolution Microscopy
(2014-10-09)Most membrane proteins are found in clusters in the plasma membrane. For abundant proteins it is apparent that the clusters also tend to have patterned distributions, rather than being randomly scattered. To reveal the ... -
Physiological functions of the adrenocortical circadian clock
(2014-09-10)In the course of evolution most organisms have evolved endogenous circadian clocks that help them to anticipate daily environmental changes in light, temperature and food availability and therefore adjust physiology and ... -
Role of cellular dynamics, adhesion and polarity in the context of primordial germ cell migration in Xenopus laevis embryos
(2014-02-11)Directional cell migration is an intensively studied process relevant for both normal development of an organism as well as for a number of pathological conditions such as chronic inflammation and cancer. Primordial germ ... -
The p53 homolog p73 takes hold of the male germ line – a novel function of TAp73 in protecting sperm cell adhesion, migration and maturation within the seminiferous epithelium of the testis
(2013-11-19)The p53 family of transcription factors possesses diverge functions in tumorigenesis and development. The evolutionarily conserved role of the family member p63 to protect the genetic stability of germ cells and influence ... -
The function of PTK7 during Xenopus neural crest migration
(2009-12-18)PTK7 is a novel component of the planar cell polarity (PCP) signaling pathway, which regulates inner ear hair cell polarity and neural tube closure, however, its signaling mechanism is ... -
Identification and analysis of JAK/STAT pathway target genes in Drosophila melanogaster
(2009-07-30)The JAK/STAT signalling cascade is one of the most conserved pathways in the animal kingdom. Aside from its developmental roles, the JAK/STAT pathway is needed for stem cell maintenance, ... -
Role of Rho GTPases During Primordial Germ Cell Migration in Zebrafish
(2008-11-26)Cell migration is an essential biological process during development, adult homeostasis, and disease. Actin cytoskeleton plays crucial role in generating forces required for cell migration. ... -
The secreted serine protease xHtrA1 is a positive feedback regulator of long-range FGF signaling.
(2007-09-13)Fibroblast growth factors (FGFs) are important signaling molecules, whose activities need to be tightly controlled. We have recently identified the Xenopus homolog of HtrA1 (xHtrA1) in a ...