Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Klumpp, Stefan Prof. Dr."
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Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ... -
Collective Behaviour of Filamentous Cyanobacteria
(2024-01-11)Cyanobacteria are the oldest phototrophic organisms on the planet. Having been responsible for the “Great Oxidation Event” millions of years ago, it has enabled the development and sustenance of multi-cellular life forms, ... -
Non-equilibrium Statistical Mechanics Studied Through the Lens of Stochastic Calculus
(2024-01-11)The microscopic world of atoms and molecules is continuously in motion, which is manifested on the macroscopic scale as a non-zero temperature. Due to collisions with surrounding molecules that perform thermal motion, many ... -
Complex Dynamics in the Spread of COVID-19
(2023-05-05)The COVID-19 pandemic is the most recent example that infectious diseases can disrupt and permanently alter how societies work and interact. This manuscript builds around a series of papers studying disease spread from the ... -
Turbulence Measurements in Flows with Particles
(2023-01-31)Despite the ubiquity of turbulent flows in nature, a general solution to the governing equations of motion remain elusive. These equations are nonlinear and nonlocal, and they describe a chaotic system with multi-scale ... -
A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation
(2022-12-14)Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ... -
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Impact of mechanically-regulated auxin transport dynamics on plant morphogenesis
(2021-10-21)Auxin is a major plant growth regulator whose interaction with cell wall properties is central to its role. Efflux carriers of this phytohormone of the PIN-FORMED family (PIN) respond to the mechanical state of the tissue. ... -
The Role of Synaptic Tagging and Capture for Memory Dynamics in Spiking Neural Networks
(2021-09-02)Memory serves to process and store information about experiences such that this information can be used in future situations. The transfer from transient storage into long-term memory, which retains information for hours, ... -
Self-organization of microtubules for biomimetic structures
(2021-07-05)Biological polymers that build up the eukaryotic cytoskeleton exhibit a rich dynamical behaviour that aid a multitude of cellular processes. Microtubules, together with their associated motor proteins in the cell are ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Molecular DNA Sensors to Measure Distribution of Cytoskeletal Forces
(2020-08-24)Actin, a major cytoskeletal biopolymer in eukaryotic cells, is crosslinked into networks of filaments and bundles. These networks are largely responsible for the maintenance of cellular shape, rigidity, and mechanical ... -
Impact of Structure Modification on Cardiomyocyte Functionality
(2020-05-28)Cardiac diseases are often related to defects in subcellular components of the heart’s main constituents, the heart muscle cells also called cardiac myocytes. These biological cells periodically contract due to ... -
Morphogenesis Control By Mechanical Stress
(2019-08-29)Morphogenesis of plants and animals often emerges from mechanical moulding and deformations. Yet, how precisely cells as individual mechanical entities can act to shape a tissue reliably and ef- ficiently is still puzzling. ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Influence of Flow and Spatial Heterogeneities on Pattern Formation of Dictyostelium discoideum
(2019-05-24)In the present cumulative thesis the reaction-diffusion equations modeling the signaling process of the social amoeba Dictyostelium discoideum were studied. The pattern formation process in this organism, corresponding to ... -
The Principles of Self-Organization of Memories in Neural Networks for Generating and Performing Cognitive Strategies
(2018-12-12)Higher-order animals exhibit the remarkable ability to dynamically adapt to a changing environment. On the neuronal level, they have to form mental representations of specific stimuli, so-called memories. Furthermore, ... -
Influence of Heterogeneities on Waves of Excitation in the Heart
(2018-08-27)In this document the interplay of a single large heterogeneity in cardiac tissue and the excitation dynamics associated with ventricuar tachycardia is investigated. Methods from non-linear dynamics are used to investigate ... -
Microalgal Adhesion to Model Substrates
(2017-12-14)Microalgae are the most important primary producers of biomass on Earth. They inherit enormous technological potential to harness photosynthesis for the sustainable production of biofuels, proteins, and food components. In ...