Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Mansouri, Ahmed Prof. Dr."
Now showing items 1-9 of 9
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Cortical patterning and neuronal migration are under the guide of BAF complex functionality
(2020-03-26)The brain is one of the complex organs designed under the control of a plethora of molecular and cellular regulatory mechanisms, including transcriptional and epigenetic pathways. Brain organogenesis proceeds in a stepwise ... -
From inside-out to outside-in: cortical lamination development in the Reelin-deficient neocortex
(2019-03-15)The adult mammalian neocortex is divided into six vertical layers, as well as into numerous specialized tangential areas that are defined by distinct cytoarchitectures and specific wiring patterns. Precise neocortical ... -
Analysis of mitochondrial transcription and replication on the single nucleoid level
(2019-03-13)Human mitochondrial DNA (mtDNA) is a circular molecule encoding for 13 subunits of the respiratory chain that are essential for its maintenance. Inside the mitochondria, mtDNA is associated with various proteins, forming ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
Function of the α/β-hydrolase fold family proteins Pummelig (CG1882) and Hormone-sensitive lipase in the Drosophila melanogaster lipid metabolism
(2016-09-30)To maintain energy homeostasis, all organisms need to adjust the generation and mobilization of their energy stores. The key molecules for energy storage are neutral lipids, mainly triacylglycerides (TAGs), which accumulate ... -
CHARGE syndrome: candidate genes and pathogenesis
(2015-09-25)CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling ... -
The role of <i>Satb2</i>, <i>Ctip2</i> and Fezl in cortical connectivity and the elucidation of their downstream pathways
(2012-06-06)Satb2 has been shown to be a key postmitotic determinant of callosal projection neurons (Alcamo et al., 2008; Britanova et al., 2008). One way by which Satb2 is acting to confer such identity involves the repression of Ctip2, ... -
Genetic Targeting and Analysis of Parvalbumin and VGLUT3 Expressing Inhibitory Interneurons
(2012-03-12)GABAergic interneurons are a highly diverse class of cell types that play essential roles in regulating the input/output behaviour of pyramidal neurons and of other interneurons. Thereby, ... -
New genetic mouse models for neurodegenerative diseases: Contribution of noradrenaline to Alzheimer’s disease pathogenesis and creation of a new genetic model for Parkinson’s disease.
(2011-12-15)Neurodegenerative diseases are among the most devastating diseases for which there are no cure to date. The greatest risk factor is advancing age. A common feature of these disorders is the toxic aggregation of a peptide ...