Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-20 of 37
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A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
Alpha-synuclein aggregation: visualization by X-ray techniques and its modulation by iron
(2017-09-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It’s a progressive disease that can be treated only symptomatically and its causes are still not fully understood. Two main factors ... -
Alpha-synuclein spreading pathology in Parkinson's disease: the influence of iron and the Rho-kinase inhibitor fasudil
(2020-06-05)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximately 1 % of the population above 60 years of age. It affects preferentially the extrapyramidal system, causing severe ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems
(2023-01-24)At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Differential metabolic alterations in cortical cell types by feeding a ketogenic diet
(2020-06-18)The suckling period of rodents is accompanied by marked ketosis as a result of the high fat content of maternal milk. During this time, ketone bodies are the major source of energy for the brain. After weaning when the ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
Functional analysis of the parkinsonism-associated protein FBXO7 (PARK15) in neurons
(2017-09-07)Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting the elderly population. It has been a challenge elucidating the molecular mechanisms underlying the selective loss of dopaminergic neurons, ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae
(2023-10-17)Alpha-synuclein (αSyn) in a misfolded state is the main component of Lewy bodies (LBs). These filamentous cytoplasmic inclusions are the neuropathological hallmark of Parkinson’s disease (PD). αSyn aggregates in LBs are ... -
Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
Mitochondrial adaptation at the neuronal presynapse
(2021-11-22)Synaptic transmission poses a major energy consuming process in the brain, but how neurons maintain a constant energy supply during extended synaptic activity and how presynaptic mitochondria contribute to the energy ...