Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-20 of 37
-
A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae
(2023-10-17)Alpha-synuclein (αSyn) in a misfolded state is the main component of Lewy bodies (LBs). These filamentous cytoplasmic inclusions are the neuropathological hallmark of Parkinson’s disease (PD). αSyn aggregates in LBs are ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems
(2023-01-24)At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarks
(2021-12-20)Amyloid pathology in Alzheimer’s disease (AD) is characterized by a heterogeneity of amyloid-β peptides (Aβ) variants. The N-terminally truncated Aβ4-42 peptides are among the most abundant species and were reported having ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ... -
Mitochondrial adaptation at the neuronal presynapse
(2021-11-22)Synaptic transmission poses a major energy consuming process in the brain, but how neurons maintain a constant energy supply during extended synaptic activity and how presynaptic mitochondria contribute to the energy ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
Resolving Dopamine Secretion at Individual Varicosities using Carbon Nanotube-Based Optical Dopamine Nanosensors
(2021-07-23)Dopamine (DA) is a neurotransmitter that controls vital brain functions such as motor control and motivation, but little is known about the molecular mechanisms that control DA release. Neurotransmission through DA differs ... -
The Synaptic RNAome - identification, interactions and intercellular transfer
(2021-03-19)Synaptic plasticity is how neurons adapt to new stimuli and necessitates changes in synaptic weight. For these changes to be durable, local translation in neurites, and at pre- and post-synapses is required. Current methods ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Differential metabolic alterations in cortical cell types by feeding a ketogenic diet
(2020-06-18)The suckling period of rodents is accompanied by marked ketosis as a result of the high fat content of maternal milk. During this time, ketone bodies are the major source of energy for the brain. After weaning when the ... -
Alpha-synuclein spreading pathology in Parkinson's disease: the influence of iron and the Rho-kinase inhibitor fasudil
(2020-06-05)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximately 1 % of the population above 60 years of age. It affects preferentially the extrapyramidal system, causing severe ... -
Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
(2019-10-25)Neurodegenerative diseases have become an increasing problem in our aging society. Many studies have addressed these complex diseases in the recent years. Scientists have learned a lot about specific proteins, their ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ...