Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Pöggeler, Stefanie Prof. Dr."
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Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae
(2023-10-17)Alpha-synuclein (αSyn) in a misfolded state is the main component of Lewy bodies (LBs). These filamentous cytoplasmic inclusions are the neuropathological hallmark of Parkinson’s disease (PD). αSyn aggregates in LBs are ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
Analysis of multiprotein-complex components pulled-down with STRIPAK in Sordaria macrospora
(2022-04-14)The striatin-interacting phosphatase and kinase (STRIPAK)-complex is highly conserved and can be found in fungi and animals. In the filamentous ascomycete Sordaria macrospora (Sm), the SmSTRIPAK plays an important role in ... -
Characterization of microbial communities in carbonate sediments
(2021-11-25)Microbial communities in carbonate sediments from the alkaline Lake Neusiedl and the Aldabra Atoll were characterized. The aim was to determine the microbial community composition and function in the context of their ... -
Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ... -
Signal transduction by the essential nucleotide second messenger cyclic di-AMP in Bacillus subtilis
(2021-01-15)Bacillus subtilis, as a soil inhabitant, has to adapt to rapidly changing osmotic conditions. The response to these osmotic changes represents one of the most critical issues in the lifecyle of bacteria, and the tight ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ... -
Insertion of an intrinsically disordered domain in VelB supports selective heterodimer formation of fungal velvet domain regulatory proteins in Aspergillus nidulans
(2019-04-10)The fungal specific velvet domain mediates DNA-binding and protein-protein interaction and is structurally similar to the Rel homology domain of the mammalian immune and infection response NF-ᴋB regulator. Homo- and ... -
Cyclic di-AMP homeostasis and osmoregulation in Listeria monocytogenes
(2019-04-05)The second messenger cyclic diadenosine monophosphate (c-di-AMP) is essential for most of the bacteria synthesizing the nucleotide. c-di-AMP is produced by diadenylate cyclases (DACs) and degraded by specific phosphodiesterases ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Proteomics of Aspergillus nidulans sexually differentiated cells
(2018-10-01)The homothallic mold Aspergillus nidulans produces as overwintering structures closed sexual fruiting bodies named cleistothecia, which contain ascospores as products of meiosis. Formation of fruiting bodies is linked to ... -
Maintenance of glutamate homeostasis in Bacillus subtilis by complex regulatory systems and genomic adaptation
(2017-10-16)The Gram-positive model organism Bacillus subtilis lives in the soil and must cope with a constantly changing environment. Glutamate plays an important role in cellular metabolism, because it is the major amino group ... -
Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ... -
Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A
(2016-01-22)Macroautophagy is a conserved catabolic pathway for the removal and recycling of cytosolic components, damaged or surplus organelles, protein aggregates or intracellular pathogens to maintain cellular homeostasis. It is ... -
The STRIPAK complex and its role in fruiting-body development of the filamentous fungus Sordaria macrospora
(2015-09-23)The mammalian Striatin-interacting phosphatase and kinase (STRIPAK) complex consist of many proteins, among them Striatin as scaffold, the putative kinase activator monopolar spindle-one-binder 3 (MOB3), serine/threonine ... -
AfuSomA transcriptional network in human pathogen Aspergillus fumigatus
(2015-05-19)Fungal development is regulated by environmental stimuli via various signaling pathways. For instance, the cyclic AMP dependent protein kinase A (PKA) cascade is controlling development or pathogenesis in fungi as filamentous ... -
Atg21 functions during autophagy as a scaffold for the E3 ubiquitin-‐like complex in Atg8 lipidation
(2015-01-23)Autophagy summarizes a family of intracellular lysosomal (vacuolar) degradative transport process. It is used for the removal and recycling of cytoplasm, protein aggregates and organelles to maintain cellular homeostasis. ...