Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wimmer, Ernst A. Prof. Dr."
Anzeige 1-20 von 28
-
An investigation of cell turnover in the planarian epidermis
(2024-04-16)Cell turnover is an important biological process for maintaining tissue homeostasis. During cell turnover, newly generated cells replace unwanted cells to balance the number of cells and ensure the functionality of a tissue. ... -
RNA Interactions of the Zebrafish Germ Plasm Organizer Bucky ball
(2023-07-24)Reproduction is the fundamental feature of all living organisms, ensuring their survival and continuance. For their reproduction, multicellular organisms develop highly specialized cells, termed germ cells. In many animals, ... -
Zebrafish as a Model for Hereditary Spastic Paraplegia
(2023-06-28)To investigate the mechanism of pathogenesis of the rare and complex neurodegenerative disorder Hereditary Spastic Paraplegia (HSP), which causes lower limb motility defects, it is crucial to establish simple and tractable ... -
Understanding Nucleosome Assembly Regulation in Drosophila melanogaster
(2022-06-24)Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ... -
Development of methods to decrease aneuploidy in mammalian oocytes
(2022-05-24)Maternal mRNAs accompany and control all processes from the onset of meiosis until the blastocyst stage when the maternal pool of mRNAs is fully replaced by the emryonic mRNA set. The successful development of blastocysts ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Thermosensory Transduction Mechanisms in Drosophila melanogaster
(2019-10-18)Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ... -
Molecular characterization and functional analysis of a novel long noncoding RNA in the mouse
(2019-05-24)Majority of mammalian transcriptomes encode long noncoding RNAs (lncRNAs) that are not translated into proteins. LncRNAs are mRNA-like transcripts that are longer than 200 nucleotides, transcribed by RNA-Pol-II and undergo ... -
The role of the FACT complex in differentiation of multipotent stem cells
(2017-04-27)Cellular differentiation is accompanied by dramatic changes in chromatin structure which are associated with the activation of lineage-specific transcriptional programs. Facilitates Chromatin Transcription (FACT) is a ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
Function of the α/β-hydrolase fold family proteins Pummelig (CG1882) and Hormone-sensitive lipase in the Drosophila melanogaster lipid metabolism
(2016-09-30)To maintain energy homeostasis, all organisms need to adjust the generation and mobilization of their energy stores. The key molecules for energy storage are neutral lipids, mainly triacylglycerides (TAGs), which accumulate ... -
Novel roles of Celf1 and Tia1 during vegetal RNA localization in Xenopus laevis oocytes
(2015-10-29)The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and germ layer formation of the future embryo. Vegetal RNA localization is mediated by signal ... -
Cellular mechanisms of odor detection in the olfactory system of the red flour beetle Tribolium castaneum
(2015-10-26)Olfaction, the detection of odors is pivotal for insects, since it leads them to food sources or mating partners and triggers important behaviors. For the detection of pheromones, CD36-related sensory neuron membrane ... -
CHARGE syndrome: candidate genes and pathogenesis
(2015-09-25)CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling ... -
MicroRNA-212/132 Family is Involved in the Regulation of Long-Term Spatial Memory and Synaptic Remodeling
(2014-10-30)MicroRNAs are noncoding transcripts with crucial functions in probably every organ system. The roles of miRNAs in neuronal processes and cognitive functions are recently being appreciated. The discovery of neuronal activity ... -
Pancreatic β-Cell Regeneration in TIF-IA Knockout Mice
(2014-09-30)As the sole source of insulin production in body, pancreatic β-cells play an essential role in glucose homeostasis. Diabetes mellitus is a chronic disease characterized by loss, reduction, and/or malfunction of β-cell mass. ... -
Functional analysis of the Drosophila gene smallish (CG43427)
(2013-09-18)The establishment and maintenance of cell polarity is crucial for the function of many cell types in multicellular organisms. Especially in epithelial tissues, cell polarity is connected to the regulation of cell adhesion ... -
Molecular correlates of spinal motor neuron functional specification and plasticity
(2013-07-30)The precision with which motor neurons connect to functionally matched muscle fibers ultimately determines the accuracy of behavioural outputs. Motor neurons are functionally diverse and can be subdivided into distinct ... -
The role of <i>Satb2</i>, <i>Ctip2</i> and Fezl in cortical connectivity and the elucidation of their downstream pathways
(2012-06-06)Satb2 has been shown to be a key postmitotic determinant of callosal projection neurons (Alcamo et al., 2008; Britanova et al., 2008). One way by which Satb2 is acting to confer such identity involves the repression of Ctip2, ... -
The function of PTK7 during Xenopus neural crest migration
(2009-12-18)PTK7 is a novel component of the planar cell polarity (PCP) signaling pathway, which regulates inner ear hair cell polarity and neural tube closure, however, its signaling mechanism is ...