Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wodarz, Andreas Prof. Dr."
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A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
Analysis of the Wnt receptors Ror, Otk and Otk2 during nervous system development in Drosophila melanogaster
(2016-01-20)Wnt signaling regulates many developmental and adult physiological processes. This is achieved through the activation of several distinct Wnt pathways. The outcome is determined by a specific combination of a Wnt ligand ... -
Attenuated apoptosis as consequence of Epithelial Mesenchymal Transition
(2014-08-14)The developmental program of Epithelial Mesenchymal Transition (EMT) is assumed to be involved in tumor progression, enabling cancer cells to spread from the primary tumor and form metastasis in distant tissues. At least ... -
Characterization of NDR kinase signalling pathways during septum formation in Neurospora crassa
(2013-11-27)Cytokinesis is a fundamental cellular process essential for cell proliferation of unicellular and multicellular organisms. The molecular pathways that regulate cytokinesis are highly complex and involve a large number of ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
CHARGE syndrome: candidate genes and pathogenesis
(2015-09-25)CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling ... -
Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny
(2015-05-06)Adult stem cells are found in most adult tissues where they are responsible for replacing cells that are lost due to turnover or injury. They have the unique ability to give rise to differentiated progeny, while at the ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Functional analysis of Prdm14 during Xenopus embryogenesis
(2016-06-23)Prdm14 is a member of the conserved family of Prdm proteins, which are emerging as crucial regulators of multiple early developmental processes and diseases. Members of the Prdm family are characterized by the presence ... -
Functional analysis of the Drosophila gene smallish (CG43427)
(2013-09-18)The establishment and maintenance of cell polarity is crucial for the function of many cell types in multicellular organisms. Especially in epithelial tissues, cell polarity is connected to the regulation of cell adhesion ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ... -
Identification and functional characterization of PTK7 ligands in Xenopus laevis
(2011-10-26)Wnt signaling pathways are evolutionary conserved and regulate numerous processes in both developing and adult organisms. The canonical Wnt signaling pathway regulates cell proliferation ... -
Molecular characterization of Ptf1a activity during Xenopus embryogenesis
(2013-08-01)A balance between inhibitory and excitatory neurons is essential for the establishment of a functional vertebrate nervous system. A key factor in regulating this balance is the bHLH transcription factor Ptf1a, which promotes ... -
Molecular mechanism of B cell antigen receptor-induced SHIP activation
(2012-03-05)Regulation of B cell activation is highly important to keep the balance between immunity and self-tolerance. The SH2 domain-containing 5 inositol phosphatase (SHIP) is an inhibitor of B ... -
Morphogenesis and Genetic Regulation of the Insect Head
(2016-09-30)Natural selection and the struggle for ecological niches were the driving force for the origin of a tremendous number of animal groups with different body shapes. The segmental organization of insects enhanced their ... -
Neuroligin 2 Induced Allosteric Transition of Collybistin Underlies Inhibitory Postsynaptic Differentiation
(2011-06-03)Synaptic inhibition is vital to brain function. GABAergic and glycinergic synapses, mediating fast inhibition in the mammalian central nervous system (CNS), balance the activity of neural circuits. At the inhibitory ... -
Olfactory Perception and Physiology in Drosophila melanogaster
(2013-05-22)All animals are able to evaluate an odor by its consequences depending on prior experiences. This includes the possibility to show a resembling response to similar odors with the same consequence as well as a distinct ... -
Physiological functions of the adrenocortical circadian clock
(2014-09-10)In the course of evolution most organisms have evolved endogenous circadian clocks that help them to anticipate daily environmental changes in light, temperature and food availability and therefore adjust physiology and ... -
PTK7 protein localization and stability is affected by canonical Wnt ligands
(2016-02-04)Wnt co-receptors have been shown to be endocytosed in response to Wnt proteins. However, the role of Wnt receptor internalization for Wnt signaling is a topic of ongoing research. Here we show that the Wnt co-receptor PTK7 ...