Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wolf, Fred Prof. Dr."
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A theory of inference and learning in cortex with spiking neurons and dendritic error computation
(2023-11-03)How the cortex performs its intricate computations, and how it adapts to the world around it, is one of the central mysteries in neuroscience. It is a longstanding belief that one of the main aims of the brain, and especially ... -
Attention: A Complex System
(2015-12-21)Experiments have elucidated the neuronal correlates of attention in the primate brain, and have led to a number of models capturing various aspects of these experiments. However, these model propose qualitatively different ... -
Cellular dynamics and stable chaos in balanced networks
(2016-01-22)A prudent approach to understanding the function of the cerebral cortex begins with understanding the repertoire of its dynamics. In this thesis, I study how interactions between single neuron properties, synaptic coupling, ... -
Chaotic Dynamics in Networks of Spiking Neurons in the Balanced State
(2011-05-30)The brain processes sensory information about the outside world in large complex networks of neurons which communicate with short electrical pulses called action potentials or spikes. The ... -
Chaotic Neural Circuit Dynamics
(2018-02-09)Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ... -
Continuous detection and prediction of grasp states and kinematics from primate motor, premotor, and parietal cortex
(2015-05-11)Neuroprosthetics aim to restore a paralyzed patient’s ability to interact with the environment, e.g., by enabling the patient to control a robot arm and hand with his or her brain activity by decoding movement intentions ... -
Decoding Cortical Motor Goal Representations in a 3D Real-World Environment
(2018-10-10)In sensorimotor neuroscience a certain motor behavior, and its underlying neuronal mechanism, is usually studied in isolation and tightly constrained by the experimental setting to provide interpretable results. When ... -
Detection and functional analysis of Ca2+ microdomains and BK channels in olfactory receptor neurons of larval Xenopus laevis
(2011-09-21)Olfactory receptor neurons (ORNs) sense odors through the interaction of odorants with their receptors, accomplishing the first step of olfactory signaling via the generation of action ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Enhancing visual cortical plasticity in mice by enriching their environment: a combined imaging and behavioural study
(2017-02-01)Brain plasticity is important not only for normal brain functions like learning and memory, but is also crucial for recovery after injuries. It has been shown that the environment has a great influence on brain plasticity. ... -
Genetic determination and layout rules of visual cortical architecture
(2017-08-30)The functional architecture of the primary visual cortex is set up by neurons that preferentially respond to visual stimuli with contours of a specific orientation in visual space. In primates and placental carnivores, ... -
Impact of stroke and enriched environment on visual cortical plasticity in mice and therapeutic interventions for rehabilitation
(2014-02-18)Stroke is a major cause of death and disability in industrialized countries. Cortical plasticity is crucial for recovery and rehabilitation after a stroke. The aims of the study were to investigate the impact of a ... -
Information, Logic, and Inference in the Analysis of Complex Networks
(2023-12-22)This thesis deals with a range of current topics in information theory and statistics. It consists of five distinct contributions: Chapter 2 focuses on the statistics of single-regression Granger causality estimators. ... -
Intercellular Coordination in Epithelial Morphogenesis
(2022-07-26)During the development of an embryo, tissue rearrangements are driven by the precisely coordinated activity of thousands of cells. How this high degree of organization is achieved and regulated is one of the most important ... -
Investigation of spatio-temporal coding in the olfactory bulb of larval Xenopus laevis using fast confocal imaging
(2009-12-04)The olfactory bulb (OB) is the only central processing station of the vertebrate olfactory system. It is assumed that odors are represented by a spatio-temporal code in the OB, with both ... -
Mathematical modeling of the structure and function of inner hair cell ribbon synapses
(2017-02-03)Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot ... -
Neuronal basis of goal-directed reach planning under reversed vision in the parietal and premotor cortices
(2013-10-09)In our everyday life we can produce goal-directed movements precisely and effortlessly, for example to saccade towards a location that you are interested in, or to reach and grasp for a cup of coffee. Goal-directed behaviors ... -
Neuronal mechanisms of the adaptation of conditional visuomotor behavior
(2011-10-20)Goal directed movements are guided by sensory inputs, which define the spatial constraints for such movements. Our vision, and also our other senses, give us information about the location ... -
Neuronal representation and attentional modulation of space and feature information in primate vision
(2017-10-17)Visual perception lays the groundwork for many activities of animals and human. Decades of neuroscience research in vision also revealed much knowledge about the general computational principles of the brain. My dissertation ...