Browsing Zentren & Graduiertenschulen by Advisor & Referee "Bähr, Mathias Prof. Dr."
Now showing items 1-8 of 8
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Visual and Auditory Perceptual Decision-Making in The Human Brain as Invesitgated by fMRI and Lesion Studies
(2017-07-27)Perceptual decision-making refers to the act of choosing one option from a set of alternatives based on the available sensory information. In this manuscript, we used model-based functional magnetic resonance imaging and ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis
(2015-03-05)The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by systemic infections. The common notion is that bacterial infections worsen disease symptoms and lead to enhanced neurodegeneration. ... -
New genetic mouse models for neurodegenerative diseases: Contribution of noradrenaline to Alzheimer’s disease pathogenesis and creation of a new genetic model for Parkinson’s disease.
(2011-12-15)Neurodegenerative diseases are among the most devastating diseases for which there are no cure to date. The greatest risk factor is advancing age. A common feature of these disorders is the toxic aggregation of a peptide ... -
SUMOylation modulates α-synuclein toxicity and fibril formation
(2010-01-18)SUMOylation is a highly dynamic posttranslational modification in which covalent attachment of the small ubiquitin-like modifier protein (SUMO) is modulating different substrate specific ... -
Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1
(2009-08-20)Neuregulin1 (NRG1), a gene on human chromosome 8p, encodes a family of widely expressed EGF-like growth factors that signal via ErbB receptors tyrosine kinases. The best understood function ... -
Glutamate-induced reversal of dopamine transport is mediated by the PKC signalling pathway
(2009-04-16)Dopaminergic neurons release their transmitter not only from axon terminals in the striatum but also from their long apical dendrites in the substantia nigra pars reticulata (SNr). Whether ... -
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
(2009-02-23)Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal ...