Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "Thoms, Sven PD Dr."
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Multiplexe optische und Rasterkraftmikroskopie für biomedizinische Bildgebung
(2020-07-03)Function or malfunction of an organism highly depend on the variety of its expressed proteins, the so-called Proteom. Science and clinical medicine have become increasingly interested in methods which precisely detect not ... -
Die Zielsteuerung peroxisomaler Membranproteine mit tail anchor
(2017-11-15)The targeting of PEX26, a peroxin involved in peroxisome biogenesis and maintenance, is similar to Pex15- its analog in baker's yeast. Both are tail anchored proteins, that share more than a common protein class and function: ... -
Auswirkungen des PPARγ-Agonisten Pioglitazon auf Peroxisomen des Gehirns im X-ALD-Mausmodell
(2017-06-13)X-linked adrenoleukodystrophy is a metabolic genetic disorder caused by inactivation of the peroxisomal ABCD1 transporter of very long chain fatty acids (VLCFs). It is characterized by progressive demyelination within the ... -
Peroxisomale Biogenese - Beteiligung Dynamin-ähnlicher Proteine und die Rolle des endoplasmatischen Retikulums
(2016-09-19)This present work deals with the peroxisomal biogenesis and should help to understand it. The work focuses on the participation of the dynamin-like protein Vps1p in the process of the peroxisomal biogenesis in S. ... -
LDHBx and MDH1x are controlled by physiological translational readthrough in Homo sapiens
(2016-04-04)A study of translational readthrough (TR) and functional translational readthrough (FTR) in Homo sapiens. Translational readthrough involves ribosomes that translate into mRNA sequences downstream of a stop codon at a ... -
Rolle der d-COP-Untereinheit im frühen sekretorischen Pfad
(2015-06-05)Intracellular communication is mediated by different pathways and signals. The ER and Golgi apparatus are communicationally connected via the COP I and II vesicles. Hereby COP I is responsible for retrograde transport ... -
Analyse des PPAR-a-Liganden Fenofibrat auf die ABCD1-defiziente Maus
(2014-07-08)The X-linked adrenoleukodystrophy is a peroxisomal hereditary metabolic disease that is due to the loss of function of the peroxisomal transmembrane transporter ABCD1. We distinguish between the frequent progressive forms ...