Browsing Human- und Zahnmedizin by Advisor "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-10 of 10
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Das Onkoprotein Mdm4 und seine Wirkung auf die DNA-Replikation
(2024-08-05)The oncoprotein MDM4, together with its family member MDM2, is one of the most important regulators of the tumor suppressor p53. This study demonstrates that loss of MDM4 in p53-deficient cells significantly compromises ... -
Cancer cell death by mitotic failure upon combined kinase inhibition
(2022-06-02)Cancer cells are prone to replicative stress to a greater extent than healthy cells are. Thus, replicative stress might be a way to target cancer cells in a more specific way than conventional chemotherapeutics do. According ... -
Investigation of genetic and translational effects of tumor suppressor proteins in two hereditary forms of renal cell carcinoma
(2021-05-07)Some familial cancer syndromes are known to cause renal cell carcinoma (RCC) in afflicted subjects. I studied the role of tumor suppressor genes in two syndromes: Birt-Hogg-Dubé (BHD) and von Hippel-Lindau (VHL). BHD is ... -
The DNA damage kinases MK2, Chk1 and the chromatin remodeling factor CHD8 determine the cellular outcome after replicative stress and DNA damage
(2021-03-26)DNA damage occurs and accumulates in every cell and is cause and consequence of cancerogenesis. Massive induction of exogenous DNA damage has its use in chemotherapy as it causes growth arrest and apoptosis in malignant ... -
Die Rolle des Tumorsuppressors p53 in der ungestörten S-Phase
(2020-12-11)The tumor suppressor protein p53 and its functional network are one of the most important means of an organism to protect a cell from the adverse effects of genotoxic stress and to prevent its malignant degeneration. Due ... -
Accumulation of single-stranded DNA in tumour cells as a result of replicative stress
(2018-01-15)Cells are constantly subjected to DNA damaging agents like reactive oxygen species, UV light or, in the case of cancer cells, chemotherapeutic drugs. All these agents can lead to replicative stress, meaning that the most ... -
Inhibition of the kinase Wee1 - Cytotoxic mechanisms and autoprotection by the tumor suppressor p53
(2017-10-27)The combination of the Wee1 inhibitor MK-1775 and gemcitabine is highly efficient in killing cancer cells in vitro and in mouse xenograft experiments, but the complete molecular mechanism of this potent sensitizing effect ... -
miR-125 regulates niche organization in Drosophila melanogaster ovary by affecting Notch signaling pathway via its target Tom
(2015-08-11)For the maintenance of tissue homeostasis upon injury or natural cell turnover, a constant source of new cells is needed. Usually these cells are delivered by tissue specific adult stem cells. ... -
Die Interaktion von ErbB2/Her2 mit Hitzeschockproteinen in Mammakarzinomzellen
(2015-01-19)Overexpression of the human epidermal growth factor receptor-2 (HER2) in breast cancer strongly correlates with aggressive tumors and poor prognosis. Recently, a positive correlation between HER2 and MIF (macrophage migration ... -
Identification of microRNA 302 as an antagonist to p63 expression
(2009-12-18)The p53-family of transcription factors is essential in tumor-suppression, during development and in tissue homeostasis. MicroRNAs are small single-stranded RNAs involved in translation ...