Browsing Human- und Zahnmedizin by Advisor "Kube, Dieter Prof. Dr."
Now showing items 1-16 of 16
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In-ovo-Untersuchungen zum Zellstoffwechsel des Hodgkin-Lymphoms
(2025-02-27)Excellent survival rates of patients with Hodgkin lymphoma (HL), a malignant neoplasm of the lymphatic system, may be compromised by acute and long-term toxicities, including infertility, cardiovascular damage, and secondary ... -
Einfluss von Tumormutationen auf die Sekretion extrazellulärer Vesikel
(2025-02-27)Extracellular vesicles (EVs) are small structures surrounded by a lipid bilayer, carrying specific cargo from their cell of origin to more distant cells, therefore functioning as vehicles in cell-to-cell communication. ... -
Interaktion von Lymphomzellen und Makrophagen in einem in-ovo-Modell
(2024-11-21)In recent years, there has been increasing evidence that the tumor microenvironment plays a varying but important role in the development of lymphomas in different types of lymphoma and influences the success of treatment. ... -
Die Auswirkungen von Tenalisib und Ruxolitinib auf Hodgkin-Lymphom-Zellen und Makrophagen sowie auf deren Interaktion
(2024-09-24)Recent research on Hodgkin lymphoma has shown that the tumor microenvironment, particularly macrophages, plays a role in the development and progression of lymphomas. The underlying mechanisms and the potential therapeutic ... -
Untersuchungen zum Serin- und Glycin-Metabolismus und der Phosphoserin-Aminotransferase 1 in der Modellzelllinie P493-6
(2023-12-18)A fundamental trait of cancer cells is the reprogramming of cell metabolism. The complex genesis of aggressive non-Hodgkin lymphoma, such as diffuse large B-cell lymphoma (DLBCL), is accompanied by conversion of cellular ... -
In-ovo-Analysen zur Interaktion von Hodgkin-Lymphomzellen mit Monozyten
(2021-10-18)Classical Hodgkin lymphoma (cHL) is an aggressive B-cell neoplasm. Despite exceptional treatment response rates, the current strategy of risk stratification in cHL implies a relevant proportion of patients being over- or ... -
Die Rolle des Transkriptionsfaktors LEF-1 im Hodgkin-Lymphom
(2019-07-26)Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas. The malignant cells in cHL form only a small part of the tumour, whereas the majority consists of a reactive infiltrate of stromal cells and ... -
IL10 und CpG induzieren über STAT3 und NF-κB die Zellproliferation und die Genexpression des Glutaminolyseenzyms GOT2 in der Modellzelllinie P493-6
(2019-05-03)The diffuse large B-cell lymphoma (DLBCL) is an aggressive Non-Hodgkin's lymphoma. A better understanding of oncogenic signaling pathways and tumor induced reprogrammed cell metabolism of these lymphomas is essential for ... -
Untersuchungen zur Angiogenese des Burkitt-Lymphoms unter besonderer Berücksichtigung des Lymphocyte enhancer-binding factor-1
(2017-11-03)Burkitt´s Lymphoma (BL), derived from abnormal germinal center B cells, is a highly malignant, aggressive Non-Hodgkins´s lymphoma. Aim of our study was to dissect the functional role of the transcription factor Lymphocyte ... -
Einfluss von LEF1 auf das Tumorwachstum im Burkitt-Lymphom-Xenograft-Modell
(2016-11-18)Because of the limited knowledge about the biology of the highly aggressive Burkitt- Lymphoma is still possible in many cases no cure, it is all the more important, Possible therapeutic approaches. One possible starting ... -
Analyse von Interleukin-10-Genvariationen bei diffus großzelligen B-Zell-Lymphomen
(2016-09-12)Although Non-Hodgkin lymphoma principally can be cured due to current therapy strategies some patients do not achieve complete remission. Besides many patients are affected by significant therapy-related toxicities. In ... -
Characterization of Interleukin 10 gene variations and serum levels as predictive factors for the clinical outcome of Non-Hodgkin Lymphoma patients and Analysis of molecular mechanisms of Interleukin 10 gene regulation in B cells
(2013-03-06)Aggressive Non-Hodgkin lymphoma (aNHL) comprises a heterogeneous group of lymphatic malignancies. Although current treatment regiments can achieve high response rates, many patients do not achieve complete remission. ... -
Identification and functional characterisation of oncogenic pathway signatures in malignant lymphoma
(2012-01-17)B cell aggressive non-Hodgkin lymphomas (aNHL) represent a heterogeneous group of lymphatic malignancies comprising Burkitt Lymphoma (BL) and Diffuse Large B cell lymphoma (DLBCL). aNHL ... -
Die Analyse der Rolle von STAT6 im klassischen Hodgkin-Lymphom
(2011-11-14)Hodgkin`s lymphoma is a common malignancie oft the lymphsystem.The role of STAT6 (signal transducer and activator of transcription) in Hodgkin´s lymphoma is not entirely revealed. The ... -
Zytokinrezeptorpolymorphismen bei Patienten mit T-Non-Hodgkin-Lymphomen
(2011-01-31)Specific variations in cytokine genes are associated with the susceptibility and prognosis of Lymphomas. In this study, the association between T-Cell-Lymphomas (T-NHL) and polymorphisms ... -
Assoziation von Genpolymorphismen der 5 flankierenden Region des Interleukin-10-Gens auf das Überleben oder die Remissionsrate beim aggressiven Non-Hodgkin-Lymphom
(2009-04-01)Non-Hodgkin"s Lymphoma (NHL) is a disease of the immune system and underlies a complex of biological processes, which are triggered by a variety of cytokines. The expression and release of ...